DegronMD

Uniprot ID: Q8TAU3

Source protein: Zinc finger protein 417

Source gene: ZNF417

Class: DEG_SIAH_1

Location: 81:89

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.5327

ASA_SCORE: 85.8889

COIL: 0.7978

CONS_SCORE: 0.3288

DSS_SCORE: 0.5733

HELIX: 0.0198

FCONS_SCORE: 0.6499

RIG_SCORE: 0.6167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C94G	TCGA-06-0648	GBM	TCGA	TPRAGVSPK	DEG_SIAH_1	0.1944
p.R75I	TCGA-99-7458	LUAD	TCGA	TPRAGVSPK	DEG_SIAH_1	0.1667
p.R75I	DO25416	LUAD	ICGC	TPRAGVSPK	DEG_SIAH_1	0.1667
p.Q78R	TCGA-AP-A1DK	UCEC	TCGA	TPRAGVSPK	DEG_SIAH_1	0.25
p.Q78R	DO42033	UCEC	ICGC	TPRAGVSPK	DEG_SIAH_1	0.25
p.S72Y	TCGA-AX-A2HC	UCEC	TCGA	TPRAGVSPK	DEG_SIAH_1	0.0833
p.S72Y	DO41572	UCEC	ICGC	TPRAGVSPK	DEG_SIAH_1	0.0833
p.T81I	TCGA-EE-A2GC	SKCM	TCGA	TPRAGVSPK	DEG_SIAH_1	0.7078
p.P82S	TCGA-VQ-A928	STAD	TCGA	TPRAGVSPK	DEG_SIAH_1	0.6752
p.P82S	DO51798	STAD	ICGC	TPRAGVSPK	DEG_SIAH_1	0.6752
p.A88T	DO44096	COAD	ICGC	TPRAGVSPK	DEG_SIAH_1	0.7139
p.E72Q	DO234202	ESAD	ICGC	TPRAGVSPK	DEG_SIAH_1	0.0833
p.E72Q	DO234285	ESAD	ICGC	TPRAGVSPK	DEG_SIAH_1	0.0833
p.E72Q	DO230659	LAML	ICGC	TPRAGVSPK	DEG_SIAH_1	0.0833
p.C93G	DO11022	GBM	ICGC	TPRAGVSPK	DEG_SIAH_1	0.2222
p.E94D	DO228781	PRAD	ICGC	TPRAGVSPK	DEG_SIAH_1	0.1944
p.T80I	DO37839	SKCM	ICGC	TPRAGVSPK	DEG_SIAH_1	0.3056
p.S79N	SIDM02050	Colorectal Carcinoma	GDSC	TPRAGVSPK	DEG_SIAH_1	0.2778
p.R83G	ACH-000951	Lung Cancer	CCLE	TPRAGVSPK	DEG_SIAH_1	0.6457
p.R83G	NCI-H2342	lung	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.6457
p.K90R	ACH-000957	Colon/Colorectal Cancer	CCLE	TPRAGVSPK	DEG_SIAH_1	0.3056
p.K90R	LS-180	large_intestine	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.3056
p.R82G	NCI-H2342	lung	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.7568
p.K89R	LS-180	large_intestine	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.6126

DegronMD: protein-targeted degradation, mutation and drug response to degrons