DegronMD

Uniprot ID: Q96SQ5

Source protein: Zinc finger protein 587

Source gene: ZNF587

Class: DEG_SIAH_1

Location: 81:89

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.6071

ASA_SCORE: 83.2222

COIL: 0.7901

CONS_SCORE: 0.3669

DSS_SCORE: 0.5733

HELIX: 0.0217

FCONS_SCORE: 1.0021

RIG_SCORE: 0.6167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P88R	DO52298	LIHC	ICGC	TPRAGVSPK	DEG_SIAH_1	0.7512
p.P82T	DO47368	SKCM	ICGC	TPRAGVSPK	DEG_SIAH_1	0.7031
p.H92N	ACH-000030	Lung Cancer	CCLE	TPRAGVSPK	DEG_SIAH_1	0.25
p.H92N	TK	haematopoietic_and_lymphoid_tissue	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.25
p.H92N	PC-14	lung	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.25
p.K89R	ACH-000901	Lung Cancer	CCLE	TPRAGVSPK	DEG_SIAH_1	0.6126
p.Q96R	451Lu	skin	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.1389
p.P88S	CP66-MEL	skin	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.6752
p.H91N	TK	haematopoietic_and_lymphoid_tissue	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.2778
p.H91N	PC-14	lung	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.2778
p.P87S	CP66-MEL	skin	COSMIC	TPRAGVSPK	DEG_SIAH_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons