DegronMD

Uniprot ID: Q5VWX1

Source protein: KH domain-containing, RNA-binding, signal transduction-associated protein 2

Source gene: KHDRBS2

Class: DEG_COP1_1

Location: 294:302

E3 ligase: COP1

DEGRON score: 0.9281

ASA_SCORE: 64.6889

COIL: 0.7864

CONS_SCORE: 0.3872

DSS_SCORE: 0.4782

HELIX: 0.1493

FCONS_SCORE: 0.9857

RIG_SCORE: 0.7839

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S298N	TCGA-18-3409	LUSC	TCGA	TQTQSVPEY	DEG_COP1_1	0.5958
p.S298N	DO26444	LUSC	ICGC	TQTQSVPEY	DEG_COP1_1	0.5958
p.S298N	DO220891	MELA	ICGC	TQTQSVPEY	DEG_COP1_1	0.5958
p.G306V	TCGA-AA-3713	COAD	TCGA	TQTQSVPEY	DEG_COP1_1	0.2222
p.G306V	DO8400	COAD	ICGC	TQTQSVPEY	DEG_COP1_1	0.2222
p.D289H	TCGA-AO-A03M	BRCA	TCGA	TQTQSVPEY	DEG_COP1_1	0.1944
p.D289H	DO2216	BRCA	ICGC	TQTQSVPEY	DEG_COP1_1	0.1944
p.A293V	TCGA-AZ-4315	COAD	TCGA	TQTQSVPEY	DEG_COP1_1	0.3056
p.A293V	DO222454	BTCA	ICGC	TQTQSVPEY	DEG_COP1_1	0.3056
p.A293V	DO8842	COAD	ICGC	TQTQSVPEY	DEG_COP1_1	0.3056
p.A293V	SIDM00499	Prostate Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.3056
p.A293V	ACH-000956	Prostate Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	0.3056
p.A293V	22RV1	prostate	COSMIC	TQTQSVPEY	DEG_COP1_1	0.3056
p.D304G	TCGA-BR-8371	STAD	TCGA	TQTQSVPEY	DEG_COP1_1	0.2778
p.D304G	DO47950	STAD	ICGC	TQTQSVPEY	DEG_COP1_1	0.2778
p.D289N	TCGA-FW-A3R5	SKCM	TCGA	TQTQSVPEY	DEG_COP1_1	0.1944
p.D289N	DO37406	SKCM	ICGC	TQTQSVPEY	DEG_COP1_1	0.1944
p.A293T	TCGA-HF-7132	STAD	TCGA	TQTQSVPEY	DEG_COP1_1	0.3056
p.A293T	DO38214	STAD	ICGC	TQTQSVPEY	DEG_COP1_1	0.3056
p.T294A	TCGA-VQ-A91V	STAD	TCGA	TQTQSVPEY	DEG_COP1_1	0.7139
p.T294A	DO222356	STAD	ICGC	TQTQSVPEY	DEG_COP1_1	0.7139
p.E301D	DO233095	GACA	ICGC	TQTQSVPEY	DEG_COP1_1	0.5647
p.N290S	DO233290	GACA	ICGC	TQTQSVPEY	DEG_COP1_1	0.2222
p.T284S	DO50952	LICA	ICGC	TQTQSVPEY	DEG_COP1_1	0.0556
p.T294I	DO50822	LIRI	ICGC	TQTQSVPEY	DEG_COP1_1	0.7078
p.D312H	DO34008	PACA	ICGC	TQTQSVPEY	DEG_COP1_1	0.0556
p.G308R	DO35083	PACA	ICGC	TQTQSVPEY	DEG_COP1_1	0.1667
p.G306S	DO228138	PBCA	ICGC	TQTQSVPEY	DEG_COP1_1	0.2222
p.S291C	SIDM00455	Pancreatic Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.25
p.S291C	ACH-000599	Pancreatic Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	0.25
p.S291C	PA-TU-8902	pancreas	COSMIC	TQTQSVPEY	DEG_COP1_1	0.25
p.T294S	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.6005
p.T294S	ACH-000769	Lung Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	0.6005
p.T294S	LK-2	lung	COSMIC	TQTQSVPEY	DEG_COP1_1	0.6005
p.Y305C	SIDM00286	Neuroblastoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.25
p.Y305C	SIDM00874	Breast Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.25
p.Y305C	SIDM00873	Non-Cancerous	GDSC	TQTQSVPEY	DEG_COP1_1	0.25
p.N290D	SIDM01045	Endometrial Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.2222
p.N290D	ACH-000978	Endometrial/Uterine Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	0.2222
p.N290D	EN	endometrium	COSMIC	TQTQSVPEY	DEG_COP1_1	0.2222
p.S310C	SIDM00971	Breast Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.1111
p.S310C	ACH-000828	Breast Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	0.1111
p.S310C	ZR-75-30	breast	COSMIC	TQTQSVPEY	DEG_COP1_1	0.1111
p.Y303H	SIDM00618	Hepatocellular Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.3056
p.Y303H	ACH-000620	Liver Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	0.3056
p.Y303H	JHH-1	liver	COSMIC	TQTQSVPEY	DEG_COP1_1	0.3056
p.P300S	SIDM00528	Breast Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.6752
p.P300S	ACH-000934	Breast Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	0.6752
p.P300S	MDA-MB-361	breast	COSMIC	TQTQSVPEY	DEG_COP1_1	0.6752
p.T296A	SIDM01387	Small Cell Lung Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TQTQSVPEY

Degron related mutations and impact score

Drug responses associated with KHDRBS2 mutations

All proteins holding degron of TQTQSVPEY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWX1	KH domain-containing, RNA-binding, signal transduction-associated protein 2	DEG_COP1_1	294:302	TQTQSVPEY	COP1	0.9281	More...