DegronMD - Q5VWX1(KHDRBS2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P214L	TCGA-06-0154	GBM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.P214L	DO12292	GBM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.R230H	TCGA-06-6695	GBM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.R230H	TCGA-OY-A56P	OV	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.R230H	DO222946	BTCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.R230H	DO13540	GBM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.R230H	DO50086	OV	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.R230H	SIDM02035	Colorectal Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.S298N	TCGA-18-3409	LUSC	TCGA	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.5958
p.S298N	DO26444	LUSC	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.5958
p.S298N	DO220891	MELA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.5958
p.R224W	TCGA-4Z-AA81	BLCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7523
p.R224W	TCGA-EB-A6R0	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7523
p.R224W	DO51868	BLCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7523
p.R224W	DO233655	GACA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7523
p.R224W	DO48646	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7523
p.T229S	TCGA-63-A5ML	LUSC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.25
p.T229S	DO219151	LUSC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.25
p.V220L	TCGA-86-8672	LUAD	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.5654
p.V220L	DO25434	LUAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.5654
p.G306V	TCGA-AA-3713	COAD	TCGA	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2222
p.G306V	DO8400	COAD	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2222
p.D289H	TCGA-AO-A03M	BRCA	TCGA	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.1944
p.D289H	DO2216	BRCA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.1944
p.T227I	TCGA-AX-A0J1	UCEC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.3056
p.T227I	DO41199	UCEC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.3056
p.A293V	TCGA-AZ-4315	COAD	TCGA	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.A293V	DO222454	BTCA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.A293V	DO8842	COAD	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.A293V	SIDM00499	Prostate Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.A293V	ACH-000956	Prostate Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.A293V	22RV1	prostate	COSMIC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.A232E	TCGA-B0-5711	KIRC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232E	DO19327	KIRC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.P212H	TCGA-BR-7851	STAD	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1111
p.P212H	DO38711	STAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1111
p.D304G	TCGA-BR-8371	STAD	TCGA	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2778
p.D304G	DO47950	STAD	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2778
p.P215L	TCGA-CD-A489	STAD	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1944
p.P215L	DO47815	STAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1944
p.R230S	TCGA-D3-A1Q6	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.R230S	DO37450	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.G219C	TCGA-D6-A74Q	HNSC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.3056
p.G219C	DO52087	HNSC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.3056
p.R224L	TCGA-DK-A2I1	BLCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7316
p.R224L	DO444	BLCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7316
p.R218Q	TCGA-DK-A6B6	BLCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2778
p.R218Q	DO48576	BLCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2778
p.R218Q	SIDM00628	Breast Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2778
p.I210N	TCGA-DX-A7EU	SARC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.0556
p.I210N	DO220040	SARC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.0556
p.G219S	TCGA-EE-A29S	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.3056
p.G219S	DO37936	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.3056
p.P213A	TCGA-EE-A2MC	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1389
p.P213A	DO37559	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1389
p.P213L	TCGA-ER-A194	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1389
p.P213L	DO47646	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1389
p.P223H	TCGA-ET-A39P	THCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7694
p.P223H	DO39576	THCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7694
p.T229I	TCGA-FS-A1Z3	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.25
p.T229I	DO37635	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.25
p.D289N	TCGA-FW-A3R5	SKCM	TCGA	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.1944
p.D289N	DO37406	SKCM	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.1944
p.P211S	TCGA-GF-A6C9	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.0833
p.P211S	TCGA-QB-AA9O	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.0833
p.P211S	DO51267	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.0833
p.P211S	DO51254	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.0833
p.A293T	TCGA-HF-7132	STAD	TCGA	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.A293T	DO38214	STAD	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.T294A	TCGA-VQ-A91V	STAD	TCGA	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.7139
p.T294A	DO222356	STAD	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.7139
p.G225E	TCGA-ZF-A9RL	BLCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6087
p.G225E	DO219078	BLCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6087
p.R230C	DO222840	COCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.2222
p.A232V	DO229016	COCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	SIDM00353	Other Sarcomas	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	SIDM00267	Biliary Tract Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	SIDM00561	Other Blood Cancers	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	SIDM00324	Neuroblastoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	KYSE-520	oesophagus	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	TGBC24TKB	biliary tract	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	RKN	ovary	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	TGW	autonomic ganglia	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	KU812	haematopoietic and lymphoid tissue	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.A232V	MLMA	haematopoietic and lymphoid tissue	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1667
p.L221H	DO234218	ESAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6202
p.L221H	DO233137	GACA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6202
p.L221R	DO234325	ESAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7316
p.L221R	DO234384	ESAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7316
p.L221P	DO234321	ESAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6471
p.L221P	DO233099	GACA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6471
p.L221P	DO36556	READ	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6471
p.E301D	DO233095	GACA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.5647
p.S226I	DO233233	GACA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7341
p.N290S	DO233290	GACA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2222
p.P215Q	DO228948	LICA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1944
p.P215Q	DO228976	LICA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.1944
p.T284S	DO50952	LICA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.0556
p.T294I	DO50822	LIRI	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.7078
p.R224Q	DO220899	MELA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6218
p.D312H	DO34008	PACA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.0556
p.G308R	DO35083	PACA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.1667
p.G306S	DO228138	PBCA	ICGC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2222
p.I210V	DO229224	THCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation rewiring degron network	0.0556
p.V220A	SIDM01293	Colorectal Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6936
p.S291C	SIDM00455	Pancreatic Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.25
p.S291C	ACH-000599	Pancreatic Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.25
p.S291C	PA-TU-8902	pancreas	COSMIC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.25
p.T294S	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.6005
p.T294S	ACH-000769	Lung Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.6005
p.T294S	LK-2	lung	COSMIC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.6005
p.Y305C	SIDM00286	Neuroblastoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.25
p.Y305C	SIDM00874	Breast Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.25
p.Y305C	SIDM00873	Non-Cancerous	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.25
p.L221I	SIDM00193	Colorectal Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6063
p.L221I	ACH-000991	Colon/Colorectal Cancer	CCLE	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6063
p.L221I	SNU-81	large intestine	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.6063
p.N290D	SIDM01045	Endometrial Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2222
p.N290D	ACH-000978	Endometrial/Uterine Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2222
p.N290D	EN	endometrium	COSMIC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.2222
p.S310C	SIDM00971	Breast Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.1111
p.S310C	ACH-000828	Breast Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.1111
p.S310C	ZR-75-30	breast	COSMIC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.1111
p.T222I	SIDM00003	Melanoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7078
p.Y303H	SIDM00618	Hepatocellular Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.Y303H	ACH-000620	Liver Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.Y303H	JHH-1	liver	COSMIC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation rewiring degron network	0.3056
p.P300S	SIDM00528	Breast Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.6752
p.P300S	ACH-000934	Breast Cancer	CCLE	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.6752
p.P300S	MDA-MB-361	breast	COSMIC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.6752
p.T296A	SIDM01387	Small Cell Lung Carcinoma	GDSC	TQTQSVPEY	DEG_COP1_1	294:302	Mutation altering degron motif	0.7139
p.P223R	ACH-000945	Lung Cancer	CCLE	VLTPRGS	DEG_SCF_FBW7_1	220:226	Mutation altering degron motif	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KHDRBS2

UniProt ID: Q5VWX1

Entrez ID: 202559

Protein name: KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (hSLM-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KHDRBS2 in