DegronMD

Uniprot ID: Q5VWX1

Source protein: KH domain-containing, RNA-binding, signal transduction-associated protein 2

Source gene: KHDRBS2

Class: DEG_SCF_FBW7_1

Location: 220:226

E3 ligase: FBXW7

DEGRON score: 0.981

ASA_SCORE: 64.7286

COIL: 0.8224

CONS_SCORE: 0.4247

DSS_SCORE: 0.7354

HELIX: 0.0247

FCONS_SCORE: 1.053

RIG_SCORE: 0.6236

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P214L	TCGA-06-0154	GBM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.P214L	DO12292	GBM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.R230H	TCGA-06-6695	GBM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.R230H	TCGA-OY-A56P	OV	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.R230H	DO222946	BTCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.R230H	DO13540	GBM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.R230H	DO50086	OV	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.R230H	SIDM02035	Colorectal Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.R224W	TCGA-4Z-AA81	BLCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.7523
p.R224W	TCGA-EB-A6R0	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.7523
p.R224W	DO51868	BLCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.7523
p.R224W	DO233655	GACA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.7523
p.R224W	DO48646	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.7523
p.T229S	TCGA-63-A5ML	LUSC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.25
p.T229S	DO219151	LUSC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.25
p.V220L	TCGA-86-8672	LUAD	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.5654
p.V220L	DO25434	LUAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.5654
p.T227I	TCGA-AX-A0J1	UCEC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.3056
p.T227I	DO41199	UCEC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.3056
p.A232E	TCGA-B0-5711	KIRC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232E	DO19327	KIRC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.P212H	TCGA-BR-7851	STAD	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.1111
p.P212H	DO38711	STAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1111
p.P215L	TCGA-CD-A489	STAD	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.1944
p.P215L	DO47815	STAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1944
p.R230S	TCGA-D3-A1Q6	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.R230S	DO37450	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.G219C	TCGA-D6-A74Q	HNSC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.3056
p.G219C	DO52087	HNSC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.3056
p.R224L	TCGA-DK-A2I1	BLCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.7316
p.R224L	DO444	BLCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.7316
p.R218Q	TCGA-DK-A6B6	BLCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.2778
p.R218Q	DO48576	BLCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.2778
p.R218Q	SIDM00628	Breast Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.2778
p.I210N	TCGA-DX-A7EU	SARC	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.0556
p.I210N	DO220040	SARC	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.0556
p.G219S	TCGA-EE-A29S	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.3056
p.G219S	DO37936	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.3056
p.P213A	TCGA-EE-A2MC	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.1389
p.P213A	DO37559	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1389
p.P213L	TCGA-ER-A194	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.1389
p.P213L	DO47646	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1389
p.P223H	TCGA-ET-A39P	THCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.7694
p.P223H	DO39576	THCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.7694
p.T229I	TCGA-FS-A1Z3	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.25
p.T229I	DO37635	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.25
p.P211S	TCGA-GF-A6C9	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.0833
p.P211S	TCGA-QB-AA9O	SKCM	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.0833
p.P211S	DO51267	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.0833
p.P211S	DO51254	SKCM	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.0833
p.G225E	TCGA-ZF-A9RL	BLCA	TCGA	VLTPRGS	DEG_SCF_FBW7_1	0.6087
p.G225E	DO219078	BLCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.6087
p.R230C	DO222840	COCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.2222
p.A232V	DO229016	COCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	SIDM00353	Other Sarcomas	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	SIDM00267	Biliary Tract Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	SIDM00561	Other Blood Cancers	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	SIDM00324	Neuroblastoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	KYSE-520	oesophagus	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	TGBC24TKB	biliary_tract	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	RKN	ovary	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	TGW	autonomic_ganglia	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.A232V	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	0.1667
p.L221H	DO234218	ESAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.6202
p.L221H	DO233137	GACA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.6202
p.L221R	DO234325	ESAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.7316
p.L221R	DO234384	ESAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.7316
p.L221P	DO234321	ESAD	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.6471
p.L221P	DO233099	GACA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.6471
p.L221P	DO36556	READ	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.6471
p.S226I	DO233233	GACA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.7341
p.P215Q	DO228948	LICA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1944
p.P215Q	DO228976	LICA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.1944
p.R224Q	DO220899	MELA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.6218
p.I210V	DO229224	THCA	ICGC	VLTPRGS	DEG_SCF_FBW7_1	0.0556
p.V220A	SIDM01293	Colorectal Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.6936
p.L221I	SIDM00193	Colorectal Carcinoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.6063
p.L221I	ACH-000991	Colon/Colorectal Cancer	CCLE	VLTPRGS	DEG_SCF_FBW7_1	0.6063
p.L221I	SNU-81	large_intestine	COSMIC	VLTPRGS	DEG_SCF_FBW7_1	0.6063
p.T222I	SIDM00003	Melanoma	GDSC	VLTPRGS	DEG_SCF_FBW7_1	0.7078
p.P223R	ACH-000945	Lung Cancer	CCLE	VLTPRGS	DEG_SCF_FBW7_1	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLTPRGS

Degron related mutations and impact score

Drug responses associated with KHDRBS2 mutations

All proteins holding degron of VLTPRGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWX1	KH domain-containing, RNA-binding, signal transduction-associated protein 2	DEG_SCF_FBW7_1	220:226	VLTPRGS	FBXW7	0.981	More...