DegronMD

Uniprot ID: P26022

Source protein: Pentraxin-related protein PTX3

Source gene: PTX3

Class: DEG_APCC_DBOX_1

Location: 159:167

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8685

ASA_SCORE: 77.5333

COIL: 0.4734

CONS_SCORE: 0.4357

DSS_SCORE: 0.1949

HELIX: 0.419

FCONS_SCORE: 1.213

RIG_SCORE: 0.8058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P176L	DO50332	ESAD	ICGC	TRADLHAVQ	DEG_APCC_DBOX_1	0.0833
p.R160L	DO51131	PRAD	ICGC	TRADLHAVQ	DEG_APCC_DBOX_1	0.8428
p.T159M	SIDM00454	Rhabdomyosarcoma	GDSC	TRADLHAVQ	DEG_APCC_DBOX_1	0.7423
p.T159M	SIDM00210	Ovarian Carcinoma	GDSC	TRADLHAVQ	DEG_APCC_DBOX_1	0.7423
p.A151T	SIDM00092	Ovarian Carcinoma	GDSC	TRADLHAVQ	DEG_APCC_DBOX_1	0.1111
p.A151T	SIDM01140	Ovarian Carcinoma	GDSC	TRADLHAVQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26022	Pentraxin-related protein PTX3	DEG_APCC_DBOX_1	159:167	TRADLHAVQ	APC,CDC20,FZR1	0.8685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons