DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
TRASLRSVL
Uniprot ID:
Q8TF76
Source protein:
Serine/threonine-protein kinase haspin
Source gene:
HASPIN
Class:
DEG_APCC_DBOX_1
Location:
237:245
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9867
ASA_SCORE:
79.7889
COIL:
0.3076
CONS_SCORE:
0.2808
DSS_SCORE:
0.4304
HELIX:
0.6566
FCONS_SCORE:
0.9988
RIG_SCORE:
0.7906
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HASPIN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TRASLRSVL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TF76
Serine/threonine-protein kinase haspin
DEG_APCC_DBOX_1
237:245
TRASLRSVL
APC,CDC20,FZR1
0.9867
More...