DegronMD

Uniprot ID: P10600

Source protein: Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

Source gene: TGFB3

Class: DEG_APCC_DBOX_1

Location: 76:84

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6862

ASA_SCORE: 87.8556

COIL: 0.3043

CONS_SCORE: 0.4448

DSS_SCORE: 0.4818

HELIX: 0.6901

FCONS_SCORE: 1.1703

RIG_SCORE: 0.7756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q68L	TCGA-A5-A0G1	UCEC	TCGA	TRELLEEMH	DEG_APCC_DBOX_1	0.1111
p.Q68L	DO42472	UCEC	ICGC	TRELLEEMH	DEG_APCC_DBOX_1	0.1111
p.P66T	TCGA-D1-A17B	UCEC	TCGA	TRELLEEMH	DEG_APCC_DBOX_1	0.0556
p.P66T	DO43017	UCEC	ICGC	TRELLEEMH	DEG_APCC_DBOX_1	0.0556
p.C91Y	TCGA-DF-A2KZ	UCEC	TCGA	TRELLEEMH	DEG_APCC_DBOX_1	0.1389
p.C91Y	DO52409	UCEC	ICGC	TRELLEEMH	DEG_APCC_DBOX_1	0.1389
p.R77Q	DO233634	GACA	ICGC	TRELLEEMH	DEG_APCC_DBOX_1	0.7329
p.L70M	SIDM01951	Colorectal Carcinoma	GDSC	TRELLEEMH	DEG_APCC_DBOX_1	0.1667
p.R77W	SIDM00217	Colorectal Carcinoma	GDSC	TRELLEEMH	DEG_APCC_DBOX_1	0.8634
p.R77W	ACH-000999	Colon/Colorectal Cancer	CCLE	TRELLEEMH	DEG_APCC_DBOX_1	0.8634
p.R77W	SNU-1040	large_intestine	COSMIC	TRELLEEMH	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10600	Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide	DEG_APCC_DBOX_1	76:84	TRELLEEMH	APC,CDC20,FZR1	0.6862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons