DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
TREVLTNIK
Uniprot ID:
Q8NDH2
Source protein:
Leucine-rich repeat transmembrane protein CCDC168
Source gene:
CCDC168
Class:
DEG_APCC_DBOX_1
Location:
4543:4551
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6686
ASA_SCORE:
100.4333
COIL:
0.6684
CONS_SCORE:
0
DSS_SCORE:
0.4591
HELIX:
0.214
FCONS_SCORE:
0
RIG_SCORE:
0.7778
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CCDC168 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TREVLTNIK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
DEG_APCC_DBOX_1
4543:4551
TREVLTNIK
APC,CDC20,FZR1
0.6686
More...