DegronMD

Uniprot ID: Q9HC62

Source protein: Sentrin-specific protease 2

Source gene: SENP2

Class: DEG_APCC_DBOX_1

Location: 278:286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 81.9889

COIL: 0.7928

CONS_SCORE: 0.2602

DSS_SCORE: 0.356

HELIX: 0.1123

FCONS_SCORE: 1.0219

RIG_SCORE: 0.7905

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C283Y	TCGA-DU-6392	LGG	TCGA	TRGPLCSLR	DEG_APCC_DBOX_1	0.5976
p.R279K	TCGA-EE-A3J8	SKCM	TCGA	TRGPLCSLR	DEG_APCC_DBOX_1	0.7237
p.R279S	DO7388	CLLE	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	0.7427
p.R280Q	DO233245	GACA	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	0.7329
p.P268L	DO233805	GACA	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	0.0556
p.V285L	DO229037	LICA	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	0.6765
p.P268S	DO51258	SKCM	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	0.0556
p.Q290K	DO47753	STAD	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	0.2222
p.K271E	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	TRGPLCSLR	DEG_APCC_DBOX_1	0.5833
p.K271E	SIDM01217	Other Blood Cancers	GDSC	TRGPLCSLR	DEG_APCC_DBOX_1	0.5833
p.K271E	SIDM01608	Endometrial Carcinoma	GDSC	TRGPLCSLR	DEG_APCC_DBOX_1	0.5833
p.K271E	SIDM01454	Kidney Carcinoma	GDSC	TRGPLCSLR	DEG_APCC_DBOX_1	0.5833
p.K271E	LC-1-sq	lung	COSMIC	TRGPLCSLR	DEG_APCC_DBOX_1	0.5833
p.K271E	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	TRGPLCSLR	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC62	Sentrin-specific protease 2	DEG_APCC_DBOX_1	278:286	TRGPLCSLR	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons