DegronMD - Q9HC62(SENP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E211D	TCGA-2W-A8YY	CESC	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.1944
p.R217Q	TCGA-B5-A0JY	UCEC	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7329
p.R217Q	TCGA-E6-A1LX	UCEC	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7329
p.R217Q	SIDM00217	Colorectal Carcinoma	GDSC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7329
p.R217Q	ACH-000999	Colon/Colorectal Cancer	CCLE	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7329
p.R217Q	SNU-1040	large intestine	COSMIC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7329
p.R222Q	TCGA-BS-A0UF	UCEC	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.6218
p.P234H	TCGA-DU-6392	LGG	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.0556
p.C283Y	TCGA-DU-6392	LGG	TCGA	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation altering degron motif	0.5976
p.R279K	TCGA-EE-A3J8	SKCM	TCGA	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation altering degron motif	0.7237
p.R279S	DO7388	CLLE	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation altering degron motif	0.7427
p.A216V	DO234427	ESAD	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.6936
p.A216V	DO38747	STAD	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.6936
p.R280Q	DO233245	GACA	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation altering degron motif	0.7329
p.P268L	DO233805	GACA	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation rewiring degron network	0.0556
p.V285L	DO229037	LICA	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation altering degron motif	0.6765
p.P208L	DO222363	MELA	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.1111
p.T222I	DO232224	PBCA	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7078
p.P268S	DO51258	SKCM	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation rewiring degron network	0.0556
p.Q290K	DO47753	STAD	ICGC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation rewiring degron network	0.2222
p.I212T	DO41903	UCEC	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.2222
p.E214Q	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.2778
p.E214Q	ACH-000837	Lung Cancer	CCLE	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.2778
p.E214Q	NCI-H322M	lung	COSMIC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.2778
p.K271E	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation blocking ubiquitination signal	0.5833
p.K271E	SIDM01217	Other Blood Cancers	GDSC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation blocking ubiquitination signal	0.5833
p.K271E	SIDM01608	Endometrial Carcinoma	GDSC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation blocking ubiquitination signal	0.5833
p.K271E	SIDM01454	Kidney Carcinoma	GDSC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation blocking ubiquitination signal	0.5833
p.K271E	LC-1-sq	lung	COSMIC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation blocking ubiquitination signal	0.5833
p.K271E	MY-M12	haematopoietic and lymphoid tissue	COSMIC	TRGPLCSLR	DEG_APCC_DBOX_1	278:286	Mutation blocking ubiquitination signal	0.5833
p.R217L	SIDM00077	Oral Cavity Carcinoma	GDSC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.8428
p.R217L	ACH-001331	Head and Neck Cancer	CCLE	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.8428
p.R217L	BICR10	upper aerodigestive tract	COSMIC	YRKLLERLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.8428

Kaplan plot for SENP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SENP2

UniProt ID: Q9HC62

Entrez ID: 59343

Protein name: Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SENP2 in