DegronMD

Uniprot ID: Q9HC62

Source protein: Sentrin-specific protease 2

Source gene: SENP2

Class: DEG_APCC_DBOX_1

Location: 216:224

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9786

ASA_SCORE: 96.4889

COIL: 0.2028

CONS_SCORE: 0.2547

DSS_SCORE: 0.5264

HELIX: 0.7839

FCONS_SCORE: 1.0665

RIG_SCORE: 0.7905

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E211D	TCGA-2W-A8YY	CESC	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	0.1944
p.R217Q	TCGA-B5-A0JY	UCEC	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	0.7329
p.R217Q	TCGA-E6-A1LX	UCEC	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	0.7329
p.R217Q	SIDM00217	Colorectal Carcinoma	GDSC	YRKLLERLK	DEG_APCC_DBOX_1	0.7329
p.R217Q	ACH-000999	Colon/Colorectal Cancer	CCLE	YRKLLERLK	DEG_APCC_DBOX_1	0.7329
p.R217Q	SNU-1040	large_intestine	COSMIC	YRKLLERLK	DEG_APCC_DBOX_1	0.7329
p.R222Q	TCGA-BS-A0UF	UCEC	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	0.6218
p.P234H	TCGA-DU-6392	LGG	TCGA	YRKLLERLK	DEG_APCC_DBOX_1	0.0556
p.A216V	DO234427	ESAD	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	0.6936
p.A216V	DO38747	STAD	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	0.6936
p.P208L	DO222363	MELA	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	0.1111
p.T222I	DO232224	PBCA	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	0.7078
p.I212T	DO41903	UCEC	ICGC	YRKLLERLK	DEG_APCC_DBOX_1	0.2222
p.E214Q	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	YRKLLERLK	DEG_APCC_DBOX_1	0.2778
p.E214Q	ACH-000837	Lung Cancer	CCLE	YRKLLERLK	DEG_APCC_DBOX_1	0.2778
p.E214Q	NCI-H322M	lung	COSMIC	YRKLLERLK	DEG_APCC_DBOX_1	0.2778
p.R217L	SIDM00077	Oral Cavity Carcinoma	GDSC	YRKLLERLK	DEG_APCC_DBOX_1	0.8428
p.R217L	ACH-001331	Head and Neck Cancer	CCLE	YRKLLERLK	DEG_APCC_DBOX_1	0.8428
p.R217L	BICR10	upper_aerodigestive_tract	COSMIC	YRKLLERLK	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC62	Sentrin-specific protease 2	DEG_APCC_DBOX_1	216:224	YRKLLERLK	APC,CDC20,FZR1	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons