DegronMD

Uniprot ID: Q9NS62

Source protein: Thrombospondin type-1 domain-containing protein 1

Source gene: THSD1

Class: DEG_APCC_DBOX_1

Location: 718:726

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.992

ASA_SCORE: 79.9

COIL: 0.8986

CONS_SCORE: 0.4266

DSS_SCORE: 0.6229

HELIX: 0.0394

FCONS_SCORE: 0.9192

RIG_SCORE: 0.6294

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A715V	TCGA-B5-A3FC	UCEC	TCGA	TRGPLNPLP	DEG_APCC_DBOX_1	0.25
p.L709M	TCGA-D1-A103	UCEC	TCGA	TRGPLNPLP	DEG_APCC_DBOX_1	0.0833
p.P726S	TCGA-EE-A20H	SKCM	TCGA	TRGPLNPLP	DEG_APCC_DBOX_1	0.5641
p.P726S	TCGA-EE-A3J4	SKCM	TCGA	TRGPLNPLP	DEG_APCC_DBOX_1	0.5641
p.P724H	TCGA-FP-A4BE	STAD	TCGA	TRGPLNPLP	DEG_APCC_DBOX_1	0.6583
p.Q733K	SIDM01144	Gastric Carcinoma	GDSC	TRGPLNPLP	DEG_APCC_DBOX_1	0.1389
p.Q733K	ACH-000303	Gastric Cancer	CCLE	TRGPLNPLP	DEG_APCC_DBOX_1	0.1389
p.Q733K	NCI-SNU-5	stomach	COSMIC	TRGPLNPLP	DEG_APCC_DBOX_1	0.1389
p.S716G	SIDM00566	Oral Cavity Carcinoma	GDSC	TRGPLNPLP	DEG_APCC_DBOX_1	0.2778
p.S716G	ACH-001625	Head and Neck Cancer	CCLE	TRGPLNPLP	DEG_APCC_DBOX_1	0.2778
p.S716G	OSC-19	upper_aerodigestive_tract	COSMIC	TRGPLNPLP	DEG_APCC_DBOX_1	0.2778
p.S736Y	CW-2	large_intestine	COSMIC	TRGPLNPLP	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS62	Thrombospondin type-1 domain-containing protein 1	DEG_APCC_DBOX_1	718:726	TRGPLNPLP	APC,CDC20,FZR1	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons