DegronMD

Uniprot ID: Q8N3D4

Source protein: EH domain-binding protein 1-like protein 1

Source gene: EHBP1L1

Class: DEG_COP1_1

Location: 866:876

E3 ligase: COP1

DEGRON score: 0.6279

ASA_SCORE: 102.0091

COIL: 0.6802

CONS_SCORE: 0.4973

DSS_SCORE: 0.4788

HELIX: 0.2102

FCONS_SCORE: 0.9718

RIG_SCORE: 0.8184

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R867C	TCGA-BR-4183	STAD	TCGA	TRKTEIIVPEA	DEG_COP1_1	0.719
p.R867C	DO38667	STAD	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.719
p.A876T	DO227603	ORCA	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.7139
p.R867H	TCGA-BR-A4QL	STAD	TCGA	TRKTEIIVPEA	DEG_COP1_1	0.7133
p.R867H	DO38723	STAD	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.7133
p.S884L	TCGA-AP-A0LM	UCEC	TCGA	TRKTEIIVPEA	DEG_COP1_1	0.5556
p.S884L	TCGA-MX-A666	STAD	TCGA	TRKTEIIVPEA	DEG_COP1_1	0.5556
p.S884L	DO222337	STAD	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.5556
p.S884L	DO43306	UCEC	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.5556
p.S884L	SIDM01229	Neuroblastoma	GDSC	TRKTEIIVPEA	DEG_COP1_1	0.5556
p.S884L	ACH-000312	Neuroblastoma	CCLE	TRKTEIIVPEA	DEG_COP1_1	0.5556
p.S884L	ACH-002217	Neuroblastoma	CCLE	TRKTEIIVPEA	DEG_COP1_1	0.5556
p.S884L	BE2-M17	autonomic_ganglia	COSMIC	TRKTEIIVPEA	DEG_COP1_1	0.5556
p.A881T	DO230342	COCA	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.1944
p.Q882E	ACH-000923	Lymphoma	CCLE	TRKTEIIVPEA	DEG_COP1_1	0.1667
p.G885R	TCGA-21-1079	LUSC	TCGA	TRKTEIIVPEA	DEG_COP1_1	0.0833
p.G885R	DO26846	LUSC	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.0833
p.G885E	TCGA-21-1079	LUSC	TCGA	TRKTEIIVPEA	DEG_COP1_1	0.0833
p.G885E	DO26846	LUSC	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.0833
p.A856S	DO231026	LUSC	ICGC	TRKTEIIVPEA	DEG_COP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3D4	EH domain-binding protein 1-like protein 1	DEG_COP1_1	866:876	TRKTEIIVPEA	COP1	0.6279	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons