DegronMD - Q8N3D4(EHBP1L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G885R	TCGA-21-1079	LUSC	TCGA	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation rewiring degron network	0.0833
p.G885R	DO26846	LUSC	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation rewiring degron network	0.0833
p.G885E	TCGA-21-1079	LUSC	TCGA	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation rewiring degron network	0.0833
p.G885E	DO26846	LUSC	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation rewiring degron network	0.0833
p.S884L	TCGA-AP-A0LM	UCEC	TCGA	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation blocking phosphorylation signal	0.5556
p.S884L	TCGA-MX-A666	STAD	TCGA	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation blocking phosphorylation signal	0.5556
p.S884L	DO222337	STAD	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation blocking phosphorylation signal	0.5556
p.S884L	DO43306	UCEC	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation blocking phosphorylation signal	0.5556
p.S884L	SIDM01229	Neuroblastoma	GDSC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation blocking phosphorylation signal	0.5556
p.S884L	ACH-000312	Neuroblastoma	CCLE	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation blocking phosphorylation signal	0.5556
p.S884L	ACH-002217	Neuroblastoma	CCLE	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation blocking phosphorylation signal	0.5556
p.S884L	BE2-M17	autonomic ganglia	COSMIC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation blocking phosphorylation signal	0.5556
p.R867C	TCGA-BR-4183	STAD	TCGA	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation altering degron motif	0.719
p.R867C	DO38667	STAD	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation altering degron motif	0.719
p.R867H	TCGA-BR-A4QL	STAD	TCGA	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation altering degron motif	0.7133
p.R867H	DO38723	STAD	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation altering degron motif	0.7133
p.T656S	TCGA-NC-A5HH	LUSC	TCGA	VIETPGTE	DEG_SCF_FBW7_2	640:647	Mutation rewiring degron network	0.0833
p.T656S	DO219187	LUSC	ICGC	VIETPGTE	DEG_SCF_FBW7_2	640:647	Mutation rewiring degron network	0.0833
p.A881T	DO230342	COCA	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation rewiring degron network	0.1944
p.E647D	DO229029	LICA	ICGC	VIETPGTE	DEG_SCF_FBW7_2	640:647	Mutation altering degron motif	0.6758
p.G630V	DO50842	LIRI	ICGC	VIETPGTE	DEG_SCF_FBW7_2	640:647	Mutation rewiring degron network	0.0556
p.A856S	DO231026	LUSC	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation rewiring degron network	0.0556
p.A876T	DO227603	ORCA	ICGC	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation altering degron motif	0.7139
p.E649Q	DO40948	UCEC	ICGC	VIETPGTE	DEG_SCF_FBW7_2	640:647	Mutation rewiring degron network	0.2778
p.V640F	SIDM01126	Small Cell Lung Carcinoma	GDSC	VIETPGTE	DEG_SCF_FBW7_2	640:647	Mutation altering degron motif	0.7068
p.V640F	SIDM01681	Non-Cancerous	GDSC	VIETPGTE	DEG_SCF_FBW7_2	640:647	Mutation altering degron motif	0.7068
p.Q882E	ACH-000923	Lymphoma	CCLE	TRKTEIIVPEA	DEG_COP1_1	866:876	Mutation rewiring degron network	0.1667

Kaplan plot for EHBP1L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EHBP1L1

UniProt ID: Q8N3D4

Entrez ID: 254102

Protein name: EH domain-binding protein 1-like protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EHBP1L1 in