DegronMD

Uniprot ID: Q8N3D4

Source protein: EH domain-binding protein 1-like protein 1

Source gene: EHBP1L1

Class: DEG_SCF_FBW7_2

Location: 640:647

E3 ligase: FBXW7

DEGRON score: 0.8759

ASA_SCORE: 89.8375

COIL: 0.8683

CONS_SCORE: 0.5007

DSS_SCORE: 0.6132

HELIX: 0.0295

FCONS_SCORE: 0.9888

RIG_SCORE: 0.7511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T656S	TCGA-NC-A5HH	LUSC	TCGA	VIETPGTE	DEG_SCF_FBW7_2	0.0833
p.T656S	DO219187	LUSC	ICGC	VIETPGTE	DEG_SCF_FBW7_2	0.0833
p.E647D	DO229029	LICA	ICGC	VIETPGTE	DEG_SCF_FBW7_2	0.6758
p.G630V	DO50842	LIRI	ICGC	VIETPGTE	DEG_SCF_FBW7_2	0.0556
p.E649Q	DO40948	UCEC	ICGC	VIETPGTE	DEG_SCF_FBW7_2	0.2778
p.V640F	SIDM01126	Small Cell Lung Carcinoma	GDSC	VIETPGTE	DEG_SCF_FBW7_2	0.7068
p.V640F	SIDM01681	Non-Cancerous	GDSC	VIETPGTE	DEG_SCF_FBW7_2	0.7068

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3D4	EH domain-binding protein 1-like protein 1	DEG_SCF_FBW7_2	640:647	VIETPGTE	FBXW7	0.8759	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons