DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_APCC_DBOX_1

Location: 278:286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6882

ASA_SCORE: 109.3889

COIL: 0.8598

CONS_SCORE: 0.5503

DSS_SCORE: 0.4226

HELIX: 0.0312

FCONS_SCORE: 0.9415

RIG_SCORE: 0.78

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P276R	TCGA-37-4141	LUSC	TCGA	TRMPLSVML	DEG_APCC_DBOX_1	0.2778
p.P276R	DO26862	LUSC	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.2778
p.V284M	TCGA-64-1676	LUAD	TCGA	TRMPLSVML	DEG_APCC_DBOX_1	0.6097
p.V284M	DO23629	LUAD	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.6097
p.V284M	DO52689	MALY	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.6097
p.R279T	TCGA-AR-A251	BRCA	TCGA	TRMPLSVML	DEG_APCC_DBOX_1	0.7876
p.R279T	DO5724	BRCA	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.7876
p.M280T	TCGA-AX-A2HD	UCEC	TCGA	TRMPLSVML	DEG_APCC_DBOX_1	0.6312
p.M280T	DO42608	UCEC	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.6312
p.G273V	TCGA-C8-A12K	BRCA	TCGA	TRMPLSVML	DEG_APCC_DBOX_1	0.1944
p.G273V	DO1258	BRCA	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.1944
p.R279S	TCGA-CV-A45W	HNSC	TCGA	TRMPLSVML	DEG_APCC_DBOX_1	0.7427
p.R279S	DO52060	HNSC	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.7427
p.R279I	TCGA-EY-A1GI	UCEC	TCGA	TRMPLSVML	DEG_APCC_DBOX_1	0.8102
p.R279I	DO41211	UCEC	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.8102
p.S283N	TCGA-FR-A7U9	SKCM	TCGA	TRMPLSVML	DEG_APCC_DBOX_1	0.5958
p.S283N	DO48546	SKCM	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.5958
p.G272E	DO229013	COCA	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.1667
p.G272E	DO229016	COCA	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.1667
p.G272E	DO229052	LICA	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.1667
p.G272E	DO230550	LUSC	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.1667
p.G272E	DO52365	LUSC	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.1667
p.V288A	DO229057	LICA	ICGC	TRMPLSVML	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_APCC_DBOX_1	278:286	TRMPLSVML	APC,CDC20,FZR1	0.6882	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons