DegronMD

Uniprot ID: Q13608

Source protein: Peroxisome assembly factor 2

Source gene: PEX6

Class: DEG_APCC_DBOX_1

Location: 141:149

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6975

ASA_SCORE: 43.8667

COIL: 0.5293

CONS_SCORE: 0.5377

DSS_SCORE: 0.4681

HELIX: 0.043

FCONS_SCORE: 1.2964

RIG_SCORE: 0.7576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q146R	DO229257	THCA	ICGC	TRPALQGLL	DEG_APCC_DBOX_1	0.6218
p.R137Q	SIDM00784	Glioma	GDSC	TRPALQGLL	DEG_APCC_DBOX_1	0.2222
p.R137Q	ACH-000126	Brain Cancer	CCLE	TRPALQGLL	DEG_APCC_DBOX_1	0.2222
p.L155V	ACH-001441	Eye Cancer	CCLE	TRPALQGLL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13608	Peroxisome assembly factor 2	DEG_APCC_DBOX_1	141:149	TRPALQGLL	APC,CDC20,FZR1	0.6975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons