DegronMD

Uniprot ID: P21217

Source protein: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

Source gene: FUT3

Class: DEG_APCC_DBOX_1

Location: 59:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6006

ASA_SCORE: 45.3778

COIL: 0.4301

CONS_SCORE: 0.4563

DSS_SCORE: 0.2892

HELIX: 0.0046

FCONS_SCORE: 1.258

RIG_SCORE: 0.8692

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R60C	TCGA-CI-6621	READ	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.8301
p.R60C	DO36970	READ	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.8301
p.R60C	SIDM01175	Other Sarcomas	GDSC	TRPTLLILL	DEG_APCC_DBOX_1	0.8301
p.R60C	SW684	soft_tissue	COSMIC	TRPTLLILL	DEG_APCC_DBOX_1	0.8301
p.R60H	DO222960	BTCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.8244
p.R60P	DO229218	THCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.7512
p.R60S	DO229018	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.7427
p.L63F	TCGA-BF-AAP4	SKCM	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.6981
p.L63F	DO219468	SKCM	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.6981
p.P61L	DO46823	RECA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.6471
p.P61R	DO51001	LAML	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.6401
p.L67I	TCGA-BS-A0UF	UCEC	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.6063
p.L67I	DO41488	UCEC	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.6063
p.T59N	DO229018	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229029	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229032	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229037	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229006	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229009	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59P	DO222842	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5919
p.T59P	DO229218	THCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5919
p.T62P	DO218874	SKCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5919
p.R68W	DO229010	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.3056
p.R68W	DO229013	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.3056
p.R68W	DO229016	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.3056

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21217	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3	DEG_APCC_DBOX_1	59:67	TRPTLLILL	APC,CDC20,FZR1	0.6006	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons