DegronMD

Uniprot ID: P21217

Source protein: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

Source gene: FUT3

Class: DEG_APCC_DBOX_1

Location: 59:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6006

ASA_SCORE: 45.3778

COIL: 0.4301

CONS_SCORE: 0.4563

DSS_SCORE: 0.2892

HELIX: 0.0046

FCONS_SCORE: 1.258

RIG_SCORE: 0.8692

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P75S	TCGA-21-1079	LUSC	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.1111
p.P75S	TCGA-D3-A51T	SKCM	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.1111
p.P75S	DO26846	LUSC	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.1111
p.P75S	DO47389	SKCM	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.1111
p.S51Y	TCGA-AG-3602	READ	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.1111
p.S51Y	DO36994	READ	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.1111
p.T56I	TCGA-AP-A059	UCEC	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.25
p.T56I	DO41361	UCEC	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.25
p.L63F	TCGA-BF-AAP4	SKCM	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.6981
p.L63F	DO219468	SKCM	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.6981
p.L67I	TCGA-BS-A0UF	UCEC	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.6063
p.L67I	DO41488	UCEC	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.6063
p.R60C	TCGA-CI-6621	READ	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.8301
p.R60C	DO36970	READ	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.8301
p.R60C	SIDM01175	Other Sarcomas	GDSC	TRPTLLILL	DEG_APCC_DBOX_1	0.8301
p.R60C	SW684	soft_tissue	COSMIC	TRPTLLILL	DEG_APCC_DBOX_1	0.8301
p.Q54H	TCGA-EE-A2MD	SKCM	TCGA	TRPTLLILL	DEG_APCC_DBOX_1	0.1944
p.Q54H	DO222434	MELA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.1944
p.Q54H	DO37851	SKCM	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.1944
p.R60H	DO222960	BTCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.8244
p.T59P	DO222842	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5919
p.T59P	DO229218	THCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5919
p.R68W	DO229010	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.3056
p.R68W	DO229013	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.3056
p.R68W	DO229016	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.3056
p.R68W	DO229003	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.3056
p.R68W	DO229005	COCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.3056
p.P61R	DO51001	LAML	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.6401
p.Q54K	DO228971	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.1944
p.T59N	DO229018	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229029	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229032	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229037	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229006	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.T59N	DO229009	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5944
p.R60S	DO229018	LICA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.7427
p.P61L	DO46823	RECA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.6471
p.T62P	DO218874	SKCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.5919
p.R60P	DO229218	THCA	ICGC	TRPTLLILL	DEG_APCC_DBOX_1	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRPTLLILL

Degron related mutations and impact score

Drug responses associated with FUT3 mutations

All proteins holding degron of TRPTLLILL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21217	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3	DEG_APCC_DBOX_1	59:67	TRPTLLILL	APC,CDC20,FZR1	0.6006	More...