DegronMD

Uniprot ID: Q6NVH7

Source protein: ATPase SWSAP1

Source gene: SWSAP1

Class: DEG_APCC_DBOX_1

Location: 41:49

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9851

ASA_SCORE: 60

COIL: 0.7662

CONS_SCORE: 0.5615

DSS_SCORE: 0.5214

HELIX: 0.086

FCONS_SCORE: 1.2405

RIG_SCORE: 0.7352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L38I	TCGA-EO-A22R	UCEC	TCGA	TRRPLQSMP	DEG_APCC_DBOX_1	0.25
p.L38I	DO42713	UCEC	ICGC	TRRPLQSMP	DEG_APCC_DBOX_1	0.25
p.G31R	TCGA-J8-A3YG	THCA	TCGA	TRRPLQSMP	DEG_APCC_DBOX_1	0.0556
p.G31R	DO39835	THCA	ICGC	TRRPLQSMP	DEG_APCC_DBOX_1	0.0556
p.Q34K	TCGA-VQ-A91D	STAD	TCGA	TRRPLQSMP	DEG_APCC_DBOX_1	0.1389
p.Q34K	DO51783	STAD	ICGC	TRRPLQSMP	DEG_APCC_DBOX_1	0.1389
p.R42L	DO229253	THCA	ICGC	TRRPLQSMP	DEG_APCC_DBOX_1	0.8428
p.L45F	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	TRRPLQSMP	DEG_APCC_DBOX_1	0.6981
p.L45F	SIDM00879	Breast Carcinoma	GDSC	TRRPLQSMP	DEG_APCC_DBOX_1	0.6981
p.L45F	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	TRRPLQSMP	DEG_APCC_DBOX_1	0.6981
p.L45F	SIDM00032	Bladder Carcinoma	GDSC	TRRPLQSMP	DEG_APCC_DBOX_1	0.6981
p.L45F	SIDM00068	Colorectal Carcinoma	GDSC	TRRPLQSMP	DEG_APCC_DBOX_1	0.6981
p.L45F	SIDM00785	Acute Myeloid Leukemia	GDSC	TRRPLQSMP	DEG_APCC_DBOX_1	0.6981
p.E32G	ACH-000264	Lung Cancer	CCLE	TRRPLQSMP	DEG_APCC_DBOX_1	0.0833
p.E32G	ACH-000581	Gastric Cancer	CCLE	TRRPLQSMP	DEG_APCC_DBOX_1	0.0833
p.E32G	ACH-000894	Lung Cancer	CCLE	TRRPLQSMP	DEG_APCC_DBOX_1	0.0833
p.E32G	ACH-002291	Embryonal Cancer	CCLE	TRRPLQSMP	DEG_APCC_DBOX_1	0.0833
p.L38F	ACH-002048	Sarcoma	CCLE	TRRPLQSMP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NVH7	ATPase SWSAP1	DEG_APCC_DBOX_1	41:49	TRRPLQSMP	APC,CDC20,FZR1	0.9851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons