DegronMD

Uniprot ID: Q06455

Source protein: Protein CBFA2T1

Source gene: RUNX1T1

Class: DEG_APCC_DBOX_1

Location: 371:379

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7277

ASA_SCORE: 80.9222

COIL: 0.2229

CONS_SCORE: 0.569

DSS_SCORE: 0.1831

HELIX: 0.7622

FCONS_SCORE: 1.2917

RIG_SCORE: 0.8652

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T387N	TCGA-75-7031	LUAD	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.1111
p.K366T	TCGA-AP-A056	UCEC	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.1944
p.E363G	TCGA-AP-A0LM	UCEC	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.1111
p.H370Y	TCGA-D3-A5GS	SKCM	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.3056
p.E363K	TCGA-EE-A20C	SKCM	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.1111
p.D369N	TCGA-EE-A29G	SKCM	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.2778
p.D377G	TCGA-EI-6917	READ	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.7198
p.M378I	TCGA-F7-7848	HNSC	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.7618
p.V388I	TCGA-HU-8602	STAD	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.0833
p.V388I	SNU-C2B	large_intestine	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.0833
p.W361R	TCGA-L9-A7SV	LUAD	TCGA	TRRSLTVLR	DEG_APCC_DBOX_1	0.0556
p.S383R	DO48447	BLCA	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.W365C	DO10300	COAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.1667
p.R367W	DO7972	COAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.R367W	DO26444	LUSC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.R367W	DO36766	READ	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.R367W	DO222332	STAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.R367W	SNU-175	large_intestine	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.R368Q	DO227976	COCA	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.25
p.R368Q	DO224688	PACA	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.25
p.H385N	DO49040	HNSC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.1667
p.D374E	DO229027	LICA	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.6758
p.S381N	DO52318	LIHC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2778
p.S383T	DO45047	LINC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.L362S	DO45323	LUAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.0833
p.G378C	DO51193	LUAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.76
p.S381I	DO26713	LUSC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2778
p.E373K	DO220891	MELA	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7022
p.A372T	DO51407	PRAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7139
p.A372T	DO40996	UCEC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7139
p.A372T	SNU-175	large_intestine	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7139
p.D371N	DO50284	SKCM	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.6932
p.S386F	DO51291	SKCM	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.1389
p.R367Q	DO48547	STAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.R368W	DO38743	STAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.25
p.R368W	UDSCC2	upper_aerodigestive_tract	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.25
p.G380D	DO47867	STAD	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.3056
p.S381C	DO42320	UCEC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2778
p.G378R	DO41927	UCEC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7568
p.E373D	DO41235	UCEC	ICGC	TRRSLTVLR	DEG_APCC_DBOX_1	0.6758
p.E373D	TE-4	oesophagus	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.6758
p.H379Q	SIDM00680	Colorectal Carcinoma	GDSC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7582
p.H379Q	LS-180	large_intestine	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7582
p.R386Q	ACH-000960	Leukemia	CCLE	TRRSLTVLR	DEG_APCC_DBOX_1	0.1389
p.R386Q	REH	haematopoietic_and_lymphoid_tissue	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.1389
p.V377I	ACH-000967	Colon/Colorectal Cancer	CCLE	TRRSLTVLR	DEG_APCC_DBOX_1	0.5965
p.V377I	ACH-001199	Colon/Colorectal Cancer	CCLE	TRRSLTVLR	DEG_APCC_DBOX_1	0.5965
p.V377I	SNU-C2B	large_intestine	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.5965
p.E387G	ACH-000978	Endometrial/Uterine Cancer	CCLE	TRRSLTVLR	DEG_APCC_DBOX_1	0.1111
p.E387G	EN	endometrium	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.1111
p.P384T	NCI-H1573	lung	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.1944
p.D371G	OVCAR-3	ovary	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7198
p.A362T	SNU-175	large_intestine	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.0833
p.R366Q	REH	haematopoietic_and_lymphoid_tissue	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.1944
p.A379T	SNU-175	large_intestine	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7139
p.D361G	OVCAR-3	ovary	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.0556
p.E363D	TE-4	oesophagus	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.1111
p.D378G	OVCAR-3	ovary	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.7198
p.R375W	UDSCC2	upper_aerodigestive_tract	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.8634
p.V368A	LNCaP-Clone-FGC	prostate	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.25
p.A388V	NCI-H1915	lung	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.0833
p.N383K	HOP-92	lung	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.V379A	LNCaP-Clone-FGC	prostate	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.6936
p.R374W	SNU-175	large_intestine	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.8634
p.E367G	EN	endometrium	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.2222
p.E380D	TE-4	oesophagus	COSMIC	TRRSLTVLR	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRRSLTVLR

Degron related mutations and impact score

Drug responses associated with RUNX1T1 mutations

All proteins holding degron of TRRSLTVLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06455	Protein CBFA2T1	DEG_APCC_DBOX_1	371:379	TRRSLTVLR	APC,CDC20,FZR1	0.7277	More...