DegronMD

Uniprot ID: Q8N412

Source protein: Sperm-tail PG-rich repeat-containing protein 2

Source gene: STPG2

Class: DEG_COP1_1

Location: 83:91

E3 ligase: COP1

DEGRON score: 0.9925

ASA_SCORE: 78.1333

COIL: 0.8896

CONS_SCORE: 0.7355

DSS_SCORE: 0.3997

HELIX: 0.016

FCONS_SCORE: 0.9925

RIG_SCORE: 0.7491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K75N	TCGA-BS-A0TC	UCEC	TCGA	TRSVDVPSI	DEG_COP1_1	0.2222
p.K75N	DO42400	UCEC	ICGC	TRSVDVPSI	DEG_COP1_1	0.2222
p.P92L	TCGA-D3-A8GI	SKCM	TCGA	TRSVDVPSI	DEG_COP1_1	0.3056
p.P92L	DO50284	SKCM	ICGC	TRSVDVPSI	DEG_COP1_1	0.3056
p.P92S	TCGA-LN-A4A8	ESCA	TCGA	TRSVDVPSI	DEG_COP1_1	0.3056
p.H101Y	TCGA-W3-AA1V	SKCM	TCGA	TRSVDVPSI	DEG_COP1_1	0.0556
p.H101Y	DO51276	SKCM	ICGC	TRSVDVPSI	DEG_COP1_1	0.0556
p.C94F	DO19048	KIRC	ICGC	TRSVDVPSI	DEG_COP1_1	0.25
p.R84G	DO52159	PAEN	ICGC	TRSVDVPSI	DEG_COP1_1	0.6457
p.G99C	DO229250	THCA	ICGC	TRSVDVPSI	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N412	Sperm-tail PG-rich repeat-containing protein 2	DEG_COP1_1	83:91	TRSVDVPSI	COP1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons