DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 13149:13159

E3 ligase: COP1

DEGRON score: 0.9364

ASA_SCORE: 77.3545

COIL: 0.9517

CONS_SCORE: 0

DSS_SCORE: 0.6091

HELIX: 0.0134

FCONS_SCORE: 0

RIG_SCORE: 0.6136

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P13159H	TCGA-17-Z030	LUAD	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.7694
p.P13155T	TCGA-18-3416	LUSC	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.5919
p.P13155T	DO26423	LUSC	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.5919
p.P13155H	TCGA-66-2754	LUSC	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.6583
p.P13155H	DO27612	LUSC	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.6583
p.T13149N	TCGA-95-7562	LUAD	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.7055
p.T13149N	DO51196	LUAD	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.7055
p.P13159S	TCGA-AA-3947	COAD	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	DO8192	COAD	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	SIDM00003	Melanoma	GDSC	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	ACH-000884	Skin Cancer	CCLE	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	ACH-002159	Skin Cancer	CCLE	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	M14	skin	COSMIC	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.G13163D	TCGA-AP-A1DV	UCEC	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.G13163D	DO43186	UCEC	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.T13161A	TCGA-BR-4366	STAD	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.T13161A	DO234413	ESAD	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.T13161A	DO38419	STAD	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.G13163S	TCGA-E7-A541	BLCA	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.G13163S	DO44037	BLCA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.V13145L	TCGA-EE-A2GB	SKCM	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.V13145L	DO222683	MELA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.V13145L	DO37417	SKCM	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.S13154F	TCGA-WE-A8ZM	SKCM	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.6871
p.S13154F	DO51284	SKCM	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.6871
p.V13167M	DO229003	COCA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.1111
p.P13168Q	DO233207	GACA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.0833
p.L13147I	DO229032	LICA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.L13147I	DO50788	LICA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.T13160K	DO229009	LICA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.3056
p.T13139P	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	TSGTPSPVPSP	DEG_COP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TSGTPSPVPSP

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of TSGTPSPVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	13149:13159	TSGTPSPVPSP	COP1	0.9364	More...