DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 13149:13159

E3 ligase: COP1

DEGRON score: 0.9364

ASA_SCORE: 77.3545

COIL: 0.9517

CONS_SCORE: 0

DSS_SCORE: 0.6091

HELIX: 0.0134

FCONS_SCORE: 0

RIG_SCORE: 0.6136

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P13159H	TCGA-17-Z030	LUAD	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.7694
p.T13149N	TCGA-95-7562	LUAD	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.7055
p.T13149N	DO51196	LUAD	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.7055
p.S13154F	TCGA-WE-A8ZM	SKCM	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.6871
p.S13154F	DO51284	SKCM	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.6871
p.P13159S	TCGA-AA-3947	COAD	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	DO8192	COAD	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	SIDM00003	Melanoma	GDSC	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	ACH-000884	Skin Cancer	CCLE	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	ACH-002159	Skin Cancer	CCLE	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13159S	M14	skin	COSMIC	TSGTPSPVPSP	DEG_COP1_1	0.6752
p.P13155H	TCGA-66-2754	LUSC	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.6583
p.P13155H	DO27612	LUSC	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.6583
p.P13155T	TCGA-18-3416	LUSC	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.5919
p.P13155T	DO26423	LUSC	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.5919
p.T13160K	DO229009	LICA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.3056
p.T13161A	TCGA-BR-4366	STAD	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.T13161A	DO234413	ESAD	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.T13161A	DO38419	STAD	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.L13147I	DO229032	LICA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.L13147I	DO50788	LICA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2778
p.G13163D	TCGA-AP-A1DV	UCEC	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.G13163D	DO43186	UCEC	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.G13163S	TCGA-E7-A541	BLCA	TCGA	TSGTPSPVPSP	DEG_COP1_1	0.2222
p.G13163S	DO44037	BLCA	ICGC	TSGTPSPVPSP	DEG_COP1_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	13149:13159	TSGTPSPVPSP	COP1	0.9364	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons