DegronMD

Uniprot ID: Q92945

Source protein: Far upstream element-binding protein 2

Source gene: KHSRP

Class: DEG_COP1_1

Location: 143:155

E3 ligase: COP1

DEGRON score: 0.9408

ASA_SCORE: 68.0308

COIL: 0.452

CONS_SCORE: 0.3005

DSS_SCORE: 0.5865

HELIX: 0.0446

FCONS_SCORE: 0.8694

RIG_SCORE: 0.7346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y149C	TCGA-DU-6392	LGG	TCGA	TSMTEEYRVPDGM	DEG_COP1_1	0.7087
p.Y149C	DO22237	LGG	ICGC	TSMTEEYRVPDGM	DEG_COP1_1	0.7087
p.R150S	TCGA-EE-A29E	SKCM	TCGA	TSMTEEYRVPDGM	DEG_COP1_1	0.6316
p.R150S	DO37831	SKCM	ICGC	TSMTEEYRVPDGM	DEG_COP1_1	0.6316
p.T146K	DO228948	LICA	ICGC	TSMTEEYRVPDGM	DEG_COP1_1	0.6195
p.T146K	DO229028	LICA	ICGC	TSMTEEYRVPDGM	DEG_COP1_1	0.6195
p.T143N	DO229045	LICA	ICGC	TSMTEEYRVPDGM	DEG_COP1_1	0.7055
p.P152Q	DO44708	LICA	ICGC	TSMTEEYRVPDGM	DEG_COP1_1	0.7035
p.L134R	DO23188	LINC	ICGC	TSMTEEYRVPDGM	DEG_COP1_1	0.0833
p.E148D	DO227554	PACA	ICGC	TSMTEEYRVPDGM	DEG_COP1_1	0.5647
p.P140T	SIDM00084	Glioblastoma	GDSC	TSMTEEYRVPDGM	DEG_COP1_1	0.25
p.D153G	SIDM00282	Colorectal Carcinoma	GDSC	TSMTEEYRVPDGM	DEG_COP1_1	0.7198
p.D153G	ACH-000998	Colon/Colorectal Cancer	CCLE	TSMTEEYRVPDGM	DEG_COP1_1	0.7198
p.D153G	CW-2	large_intestine	COSMIC	TSMTEEYRVPDGM	DEG_COP1_1	0.7198
p.S144L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	TSMTEEYRVPDGM	DEG_COP1_1	0.8778
p.S144L	ACH-000995	Leukemia	CCLE	TSMTEEYRVPDGM	DEG_COP1_1	0.8778
p.S144L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TSMTEEYRVPDGM	DEG_COP1_1	0.8778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92945	Far upstream element-binding protein 2	DEG_COP1_1	143:155	TSMTEEYRVPDGM	COP1	0.9408	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons