DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 307:317

E3 ligase: COP1

DEGRON score: 0.9937

ASA_SCORE: 89.4727

COIL: 0.9421

CONS_SCORE: 0

DSS_SCORE: 0.545

HELIX: 0.0169

FCONS_SCORE: 0

RIG_SCORE: 0.6384

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S311P	TCGA-49-AARE	LUAD	TCGA	TSPLSPGVPEA	DEG_COP1_1	0.7863
p.S311P	DO218922	LUAD	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.7863
p.I300K	TCGA-97-8172	LUAD	TCGA	TSPLSPGVPEA	DEG_COP1_1	0.1389
p.I300K	DO26384	LUAD	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.1389
p.S302T	TCGA-L5-A88Y	ESCA	TCGA	TSPLSPGVPEA	DEG_COP1_1	0.1944
p.S302L	TCGA-RA-A741	CESC	TCGA	TSPLSPGVPEA	DEG_COP1_1	0.1944
p.S302L	DO49013	CESC	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.1944
p.E316K	TCGA-WE-AAA4	SKCM	TCGA	TSPLSPGVPEA	DEG_COP1_1	0.7022
p.E316K	DO51296	SKCM	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.7022
p.P312L	DO225258	BRCA	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.6471
p.S302A	DO227995	COCA	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.1944
p.E297D	DO222482	ESCA	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.0556
p.E297D	SIDM00681	Colorectal Carcinoma	GDSC	TSPLSPGVPEA	DEG_COP1_1	0.0556
p.E297D	ACH-000252	Colon/Colorectal Cancer	CCLE	TSPLSPGVPEA	DEG_COP1_1	0.0556
p.E297D	LS-1034	large_intestine	COSMIC	TSPLSPGVPEA	DEG_COP1_1	0.0556
p.F301L	DO228343	MALY	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.1667
p.S308F	DO222638	MELA	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.7982
p.S308F	SIDM00545	Melanoma	GDSC	TSPLSPGVPEA	DEG_COP1_1	0.7982
p.S308F	SIDM00568	Gastric Carcinoma	GDSC	TSPLSPGVPEA	DEG_COP1_1	0.7982
p.S308F	ACH-000247	Gastric Cancer	CCLE	TSPLSPGVPEA	DEG_COP1_1	0.7982
p.S308F	ACH-000987	Skin Cancer	CCLE	TSPLSPGVPEA	DEG_COP1_1	0.7982
p.S308F	OCUM-1	stomach	COSMIC	TSPLSPGVPEA	DEG_COP1_1	0.7982
p.S308F	Mewo	skin	COSMIC	TSPLSPGVPEA	DEG_COP1_1	0.7982
p.S305N	DO229502	SKCA	ICGC	TSPLSPGVPEA	DEG_COP1_1	0.2778
p.G313E	SIDM00057	Neuroblastoma	GDSC	TSPLSPGVPEA	DEG_COP1_1	0.6087
p.G313E	ACH-000676	Brain Cancer	CCLE	TSPLSPGVPEA	DEG_COP1_1	0.6087
p.G313E	ACH-002389	Neuroblastoma	CCLE	TSPLSPGVPEA	DEG_COP1_1	0.6087
p.G313E	ACN	autonomic_ganglia	COSMIC	TSPLSPGVPEA	DEG_COP1_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	307:317	TSPLSPGVPEA	COP1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TSPLSPGVPEA

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of TSPLSPGVPEA