DegronMD

Uniprot ID: Q2KHR3

Source protein: Glutamine and serine-rich protein 1

Source gene: QSER1

Class: DEG_COP1_1

Location: 104:112

E3 ligase: COP1

DEGRON score: 0.9768

ASA_SCORE: 80.4889

COIL: 0.8756

CONS_SCORE: 0.635

DSS_SCORE: 0.3558

HELIX: 0.0924

FCONS_SCORE: 1.005

RIG_SCORE: 0.7509

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L99F	TCGA-CJ-6028	KIRC	TCGA	TSQGTVPTA	DEG_COP1_1	0.1944
p.L99F	DO16803	KIRC	ICGC	TSQGTVPTA	DEG_COP1_1	0.1944
p.S94G	TCGA-D3-A8GQ	SKCM	TCGA	TSQGTVPTA	DEG_COP1_1	0.0556
p.S94G	DO51246	SKCM	ICGC	TSQGTVPTA	DEG_COP1_1	0.0556
p.H95D	TCGA-D8-A1JA	BRCA	TCGA	TSQGTVPTA	DEG_COP1_1	0.0833
p.H95D	DO2819	BRCA	ICGC	TSQGTVPTA	DEG_COP1_1	0.0833
p.E116Q	TCGA-DV-5565	KIRC	TCGA	TSQGTVPTA	DEG_COP1_1	0.2222
p.E116Q	DO19693	KIRC	ICGC	TSQGTVPTA	DEG_COP1_1	0.2222
p.E116K	DO220891	MELA	ICGC	TSQGTVPTA	DEG_COP1_1	0.2222
p.V109I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM01196	Hepatocellular Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM00574	Glioblastoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM00580	Acute Myeloid Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM00996	Thyroid Gland Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM00603	Head and Neck Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM01693	B-Lymphoblastic Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM01464	Pancreatic Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V109I	SIDM00497	Colorectal Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.7076
p.V122A	SIDM00845	Burkitt's Lymphoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.0556
p.V122A	SIDM00035	Thyroid Gland Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.0556
p.V122A	SIDM00461	Acute Myeloid Leukemia	GDSC	TSQGTVPTA	DEG_COP1_1	0.0556
p.V122A	SIDM01519	Head and Neck Carcinoma	GDSC	TSQGTVPTA	DEG_COP1_1	0.0556
p.V122A	ACH-000786	Lymphoma	CCLE	TSQGTVPTA	DEG_COP1_1	0.0556
p.V122A	ACH-000992	Head and Neck Cancer	CCLE	TSQGTVPTA	DEG_COP1_1	0.0556
p.V122A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	TSQGTVPTA	DEG_COP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TSQGTVPTA

Degron related mutations and impact score

Drug responses associated with QSER1 mutations

All proteins holding degron of TSQGTVPTA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR3	Glutamine and serine-rich protein 1	DEG_COP1_1	104:112	TSQGTVPTA	COP1	0.9768	More...