DegronMD

Uniprot ID: Q5VUA4

Source protein: Zinc finger protein 318

Source gene: ZNF318

Class: DEG_COP1_1

Location: 807:818

E3 ligase: COP1

DEGRON score: 0.8751

ASA_SCORE: 88.5667

COIL: 0.9642

CONS_SCORE: 0.3822

DSS_SCORE: 0.5886

HELIX: 0.0149

FCONS_SCORE: 0.9215

RIG_SCORE: 0.5876

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E817Q	TCGA-DR-A0ZM	CESC	TCGA	TSQPSNHPVPEP	DEG_COP1_1	0.6744
p.E817Q	DO6254	CESC	ICGC	TSQPSNHPVPEP	DEG_COP1_1	0.6744
p.P810Q	TCGA-FS-A1ZB	SKCM	TCGA	TSQPSNHPVPEP	DEG_COP1_1	0.5924
p.P810Q	DO37886	SKCM	ICGC	TSQPSNHPVPEP	DEG_COP1_1	0.5924
p.Q809E	TCGA-IR-A3LA	CESC	TCGA	TSQPSNHPVPEP	DEG_COP1_1	0.5633
p.Q809E	DO44377	CESC	ICGC	TSQPSNHPVPEP	DEG_COP1_1	0.5633
p.P823T	DO229022	LICA	ICGC	TSQPSNHPVPEP	DEG_COP1_1	0.1944
p.P823T	DO229038	LICA	ICGC	TSQPSNHPVPEP	DEG_COP1_1	0.1944
p.A828D	DO229026	LICA	ICGC	TSQPSNHPVPEP	DEG_COP1_1	0.0556
p.T825I	DO219878	SKCA	ICGC	TSQPSNHPVPEP	DEG_COP1_1	0.5833
p.A828T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	TSQPSNHPVPEP	DEG_COP1_1	0.0556
p.A828T	ACH-000981	Leukemia	CCLE	TSQPSNHPVPEP	DEG_COP1_1	0.0556
p.A828T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	TSQPSNHPVPEP	DEG_COP1_1	0.0556
p.K826R	SIDM00272	Breast Carcinoma	GDSC	TSQPSNHPVPEP	DEG_COP1_1	0.2222
p.K826R	ACH-000910	Breast Cancer	CCLE	TSQPSNHPVPEP	DEG_COP1_1	0.2222
p.K826R	MDA-MB-453	breast	COSMIC	TSQPSNHPVPEP	DEG_COP1_1	0.2222
p.N812S	SIDM01133	Other Solid Cancers	GDSC	TSQPSNHPVPEP	DEG_COP1_1	0.5958
p.N812S	ACH-000635	Ovarian Cancer	CCLE	TSQPSNHPVPEP	DEG_COP1_1	0.5958
p.N812S	ACH-002177	Lung Cancer	CCLE	TSQPSNHPVPEP	DEG_COP1_1	0.5958
p.N812S	NCI-H835	lung	COSMIC	TSQPSNHPVPEP	DEG_COP1_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VUA4	Zinc finger protein 318	DEG_COP1_1	807:818	TSQPSNHPVPEP	COP1	0.8751	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons