DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 11754:11761

E3 ligase: COP1

DEGRON score: 0.9604

ASA_SCORE: 83.6625

COIL: 0.8286

CONS_SCORE: 0

DSS_SCORE: 0.6421

HELIX: 0.0134

FCONS_SCORE: 0

RIG_SCORE: 0.6728

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11768S	TCGA-A5-A0G1	UCEC	TCGA	TSTTVPTL	DEG_COP1_1	0.1389
p.P11768S	DO42472	UCEC	ICGC	TSTTVPTL	DEG_COP1_1	0.1389
p.S11764F	TCGA-AG-A002	READ	TCGA	TSTTVPTL	DEG_COP1_1	0.6944
p.P11765S	TCGA-D3-A51G	SKCM	TCGA	TSTTVPTL	DEG_COP1_1	0.2222
p.P11765S	TCGA-D3-A8GC	SKCM	TCGA	TSTTVPTL	DEG_COP1_1	0.2222
p.P11765S	DO50281	SKCM	ICGC	TSTTVPTL	DEG_COP1_1	0.2222
p.P11765S	DO47700	SKCM	ICGC	TSTTVPTL	DEG_COP1_1	0.2222
p.T11760N	TCGA-DU-5854	LGG	TCGA	TSTTVPTL	DEG_COP1_1	0.8166
p.T11760N	DO22466	LGG	ICGC	TSTTVPTL	DEG_COP1_1	0.8166
p.E11769K	TCGA-FI-A2D0	UCEC	TCGA	TSTTVPTL	DEG_COP1_1	0.1111
p.E11769K	DO43891	UCEC	ICGC	TSTTVPTL	DEG_COP1_1	0.1111
p.T11770A	TCGA-IB-7651	PAAD	TCGA	TSTTVPTL	DEG_COP1_1	0.5278
p.T11770A	DO46657	PAAD	ICGC	TSTTVPTL	DEG_COP1_1	0.5278
p.T11744N	DO224668	COCA	ICGC	TSTTVPTL	DEG_COP1_1	0.0556
p.T11744P	DO232761	PBCA	ICGC	TSTTVPTL	DEG_COP1_1	0.0556
p.V11758I	SIDM00227	Neuroblastoma	GDSC	TSTTVPTL	DEG_COP1_1	0.7076
p.V11758I	ACH-001344	Neuroblastoma	CCLE	TSTTVPTL	DEG_COP1_1	0.7076
p.V11758I	GI-ME-N	autonomic_ganglia	COSMIC	TSTTVPTL	DEG_COP1_1	0.7076
p.S11745L	SIDM00146	Breast Carcinoma	GDSC	TSTTVPTL	DEG_COP1_1	0.5278
p.S11745L	ACH-000768	Breast Cancer	CCLE	TSTTVPTL	DEG_COP1_1	0.5278
p.S11745L	MDA-MB-231	breast	COSMIC	TSTTVPTL	DEG_COP1_1	0.5278
p.Q11746E	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	TSTTVPTL	DEG_COP1_1	0.1111
p.Q11746E	KYSE-450	oesophagus	COSMIC	TSTTVPTL	DEG_COP1_1	0.1111
p.S11755N	SIDM01128	Small Cell Lung Carcinoma	GDSC	TSTTVPTL	DEG_COP1_1	0.7069
p.S11755N	ACH-000767	Lung Cancer	CCLE	TSTTVPTL	DEG_COP1_1	0.7069
p.S11755N	NCI-H526	lung	COSMIC	TSTTVPTL	DEG_COP1_1	0.7069
p.T11770S	SIDM01660	Kidney Carcinoma	GDSC	TSTTVPTL	DEG_COP1_1	0.5278
p.T11770S	ACH-000709	Kidney Cancer	CCLE	TSTTVPTL	DEG_COP1_1	0.5278
p.S11749R	ACH-001030	Bone Cancer	CCLE	TSTTVPTL	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TSTTVPTL

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of TSTTVPTL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	11754:11761	TSTTVPTL	COP1	0.9604	More...