DegronMD

Uniprot ID: Q9Y675

Source protein: SNRPN upstream reading frame protein

Source gene: SNURF

Class: DEG_COP1_1

Location: 13:21

E3 ligase: COP1

DEGRON score: 0.9689

ASA_SCORE: 76.7778

COIL: 0.6247

CONS_SCORE: 0.9738

DSS_SCORE: 0.4799

HELIX: 0.2447

FCONS_SCORE: 0.9939

RIG_SCORE: 0.7166

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R27G	TCGA-13-2057	OV	TCGA	TTEQHVPEV	DEG_COP1_1	0.1667
p.R27G	DO31320	OV	ICGC	TTEQHVPEV	DEG_COP1_1	0.1667
p.V18I	TCGA-2W-A8YY	CESC	TCGA	TTEQHVPEV	DEG_COP1_1	0.7076
p.V18I	DO223732	CESC	ICGC	TTEQHVPEV	DEG_COP1_1	0.7076
p.V18I	DO23320	LINC	ICGC	TTEQHVPEV	DEG_COP1_1	0.7076
p.V18L	TCGA-69-7765	LUAD	TCGA	TTEQHVPEV	DEG_COP1_1	0.6765
p.V18L	DO228952	LICA	ICGC	TTEQHVPEV	DEG_COP1_1	0.6765
p.V18L	DO23580	LUAD	ICGC	TTEQHVPEV	DEG_COP1_1	0.6765
p.R3W	TCGA-AR-A0TZ	BRCA	TCGA	TTEQHVPEV	DEG_COP1_1	0.5
p.R3W	DO2287	BRCA	ICGC	TTEQHVPEV	DEG_COP1_1	0.5
p.V21L	TCGA-CV-A45Z	HNSC	TCGA	TTEQHVPEV	DEG_COP1_1	0.5654
p.V21L	DO52064	HNSC	ICGC	TTEQHVPEV	DEG_COP1_1	0.5654
p.R12Q	TCGA-DA-A95X	SKCM	TCGA	TTEQHVPEV	DEG_COP1_1	0.3056
p.R12Q	DO9876	COAD	ICGC	TTEQHVPEV	DEG_COP1_1	0.3056
p.R12Q	DO219480	SKCM	ICGC	TTEQHVPEV	DEG_COP1_1	0.3056
p.R7H	TCGA-DU-6392	LGG	TCGA	TTEQHVPEV	DEG_COP1_1	0.1667
p.R7H	DO233163	GACA	ICGC	TTEQHVPEV	DEG_COP1_1	0.1667
p.R7H	DO22237	LGG	ICGC	TTEQHVPEV	DEG_COP1_1	0.1667
p.E22D	TCGA-FS-A1ZC	SKCM	TCGA	TTEQHVPEV	DEG_COP1_1	0.3056
p.E22D	DO37487	SKCM	ICGC	TTEQHVPEV	DEG_COP1_1	0.3056
p.R7C	TCGA-GN-A266	SKCM	TCGA	TTEQHVPEV	DEG_COP1_1	0.1667
p.R7C	TCGA-W3-AA1R	SKCM	TCGA	TTEQHVPEV	DEG_COP1_1	0.1667
p.R7C	DO37432	SKCM	ICGC	TTEQHVPEV	DEG_COP1_1	0.1667
p.R7C	DO51275	SKCM	ICGC	TTEQHVPEV	DEG_COP1_1	0.1667
p.R7G	DO1087	BRCA	ICGC	TTEQHVPEV	DEG_COP1_1	0.1667
p.A31V	DO227984	COCA	ICGC	TTEQHVPEV	DEG_COP1_1	0.0556
p.R11G	DO233168	GACA	ICGC	TTEQHVPEV	DEG_COP1_1	0.2778
p.R3Q	DO233671	GACA	ICGC	TTEQHVPEV	DEG_COP1_1	0.5
p.V25L	ACH-000847	Gastric Cancer	CCLE	TTEQHVPEV	DEG_COP1_1	0.2222
p.V25L	HGC-27	stomach	COSMIC	TTEQHVPEV	DEG_COP1_1	0.2222
p.R7S	ACH-001364	Lung Cancer	CCLE	TTEQHVPEV	DEG_COP1_1	0.1667
p.R7S	NCI-H345	lung	COSMIC	TTEQHVPEV	DEG_COP1_1	0.1667
p.P19Q	ACH-002175	Lung Cancer	CCLE	TTEQHVPEV	DEG_COP1_1	0.7035
p.P19Q	NCI-H740	lung	COSMIC	TTEQHVPEV	DEG_COP1_1	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TTEQHVPEV

Degron related mutations and impact score

Drug responses associated with SNURF mutations

All proteins holding degron of TTEQHVPEV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y675	SNRPN upstream reading frame protein	DEG_COP1_1	13:21	TTEQHVPEV	COP1	0.9689	More...