DegronMD

Uniprot ID: Q6UWJ8

Source protein: CD164 sialomucin-like 2 protein

Source gene: CD164L2

Class: DEG_COP1_1

Location: 123:132

E3 ligase: COP1

DEGRON score: 0.9104

ASA_SCORE: 78.33

COIL: 0.9329

CONS_SCORE: 0.5365

DSS_SCORE: 0.5781

HELIX: 0.0244

FCONS_SCORE: 0.738

RIG_SCORE: 0.6301

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P119L	TCGA-BT-A20V	BLCA	TCGA	TTGSPPVPEA	DEG_COP1_1	0.2222
p.P119L	DO689	BLCA	ICGC	TTGSPPVPEA	DEG_COP1_1	0.2222
p.P128T	TCGA-EE-A3AD	SKCM	TCGA	TTGSPPVPEA	DEG_COP1_1	0.5919
p.P128T	DO37707	SKCM	ICGC	TTGSPPVPEA	DEG_COP1_1	0.5919
p.P115H	TCGA-FS-A1ZP	SKCM	TCGA	TTGSPPVPEA	DEG_COP1_1	0.1111
p.P115H	DO37703	SKCM	ICGC	TTGSPPVPEA	DEG_COP1_1	0.1111
p.A115E	DO14159	HNSC	ICGC	TTGSPPVPEA	DEG_COP1_1	0.1111
p.T123K	DO228986	LICA	ICGC	TTGSPPVPEA	DEG_COP1_1	0.7306
p.P129T	DO229022	LICA	ICGC	TTGSPPVPEA	DEG_COP1_1	0.7031
p.L123I	DO229022	LICA	ICGC	TTGSPPVPEA	DEG_COP1_1	0.7174
p.E131D	SIDM01293	Colorectal Carcinoma	GDSC	TTGSPPVPEA	DEG_COP1_1	0.5647
p.S134G	SIDM00789	Colorectal Carcinoma	GDSC	TTGSPPVPEA	DEG_COP1_1	0.2778
p.S134G	ACH-000997	Colon/Colorectal Cancer	CCLE	TTGSPPVPEA	DEG_COP1_1	0.2778
p.S134G	HCT-15	large_intestine	COSMIC	TTGSPPVPEA	DEG_COP1_1	0.2778
p.A132T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TTGSPPVPEA	DEG_COP1_1	0.7139
p.A132T	ACH-002256	Leukemia	CCLE	TTGSPPVPEA	DEG_COP1_1	0.7139
p.A132T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TTGSPPVPEA	DEG_COP1_1	0.7139
p.G125E	SIDM00003	Melanoma	GDSC	TTGSPPVPEA	DEG_COP1_1	0.6087
p.G125E	M14	skin	COSMIC	TTGSPPVPEA	DEG_COP1_1	0.6087
p.Y117S	ACH-001541	Myeloma	CCLE	TTGSPPVPEA	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UWJ8	CD164 sialomucin-like 2 protein	DEG_COP1_1	123:132	TTGSPPVPEA	COP1	0.9104	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons