DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 886:896

E3 ligase: COP1

DEGRON score: 0.9636

ASA_SCORE: 89.5273

COIL: 0.9194

CONS_SCORE: 0

DSS_SCORE: 0.4894

HELIX: 0.0162

FCONS_SCORE: 0

RIG_SCORE: 0.7097

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S892C	TCGA-18-4083	LUSC	TCGA	TTLASTSVPTP	DEG_COP1_1	0.643
p.S892C	DO26504	LUSC	ICGC	TTLASTSVPTP	DEG_COP1_1	0.643
p.R883K	TCGA-60-2709	LUSC	TCGA	TTLASTSVPTP	DEG_COP1_1	0.25
p.R883K	DO27096	LUSC	ICGC	TTLASTSVPTP	DEG_COP1_1	0.25
p.R885M	TCGA-BF-AAP1	SKCM	TCGA	TTLASTSVPTP	DEG_COP1_1	0.3056
p.R885M	DO219464	SKCM	ICGC	TTLASTSVPTP	DEG_COP1_1	0.3056
p.P896Q	TCGA-D3-A3CB	SKCM	TCGA	TTLASTSVPTP	DEG_COP1_1	0.7035
p.P896Q	DO47386	SKCM	ICGC	TTLASTSVPTP	DEG_COP1_1	0.7035
p.P899L	TCGA-DA-A3F8	SKCM	TCGA	TTLASTSVPTP	DEG_COP1_1	0.25
p.P899L	DO37418	SKCM	ICGC	TTLASTSVPTP	DEG_COP1_1	0.25
p.P896L	TCGA-EE-A20C	SKCM	TCGA	TTLASTSVPTP	DEG_COP1_1	0.6471
p.P896L	DO222775	MELA	ICGC	TTLASTSVPTP	DEG_COP1_1	0.6471
p.P896L	DO47665	SKCM	ICGC	TTLASTSVPTP	DEG_COP1_1	0.6471
p.P894H	TCGA-EE-A29M	SKCM	TCGA	TTLASTSVPTP	DEG_COP1_1	0.7694
p.P894H	DO37404	SKCM	ICGC	TTLASTSVPTP	DEG_COP1_1	0.7694
p.S880F	TCGA-MY-A913	CESC	TCGA	TTLASTSVPTP	DEG_COP1_1	0.1667
p.S880F	DO49980	CESC	ICGC	TTLASTSVPTP	DEG_COP1_1	0.1667
p.E878D	TCGA-ND-A4WC	UCS	TCGA	TTLASTSVPTP	DEG_COP1_1	0.1111
p.S892F	TCGA-W3-A825	SKCM	TCGA	TTLASTSVPTP	DEG_COP1_1	0.6871
p.S892F	DO51272	SKCM	ICGC	TTLASTSVPTP	DEG_COP1_1	0.6871
p.S880Y	DO222762	COCA	ICGC	TTLASTSVPTP	DEG_COP1_1	0.1667
p.A889V	DO222864	COCA	ICGC	TTLASTSVPTP	DEG_COP1_1	0.5825
p.E878K	DO233935	GACA	ICGC	TTLASTSVPTP	DEG_COP1_1	0.1111
p.P899S	DO37432	SKCM	ICGC	TTLASTSVPTP	DEG_COP1_1	0.25
p.P899S	SIDM00336	Melanoma	GDSC	TTLASTSVPTP	DEG_COP1_1	0.25
p.P899S	ACH-000881	Skin Cancer	CCLE	TTLASTSVPTP	DEG_COP1_1	0.25
p.P899S	MEL-JUSO	skin	COSMIC	TTLASTSVPTP	DEG_COP1_1	0.25
p.L888M	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	TTLASTSVPTP	DEG_COP1_1	0.5999
p.L888M	ACH-000841	Lung Cancer	CCLE	TTLASTSVPTP	DEG_COP1_1	0.5999
p.L888M	NCI-H2087	lung	COSMIC	TTLASTSVPTP	DEG_COP1_1	0.5999
p.T879I	SIDM00537	Colorectal Carcinoma	GDSC	TTLASTSVPTP	DEG_COP1_1	0.1389
p.T879I	ACH-000982	Colon/Colorectal Cancer	CCLE	TTLASTSVPTP	DEG_COP1_1	0.1389
p.T879I	ACH-001345	Colon/Colorectal Cancer	CCLE	TTLASTSVPTP	DEG_COP1_1	0.1389
p.T879I	GP5d	large_intestine	COSMIC	TTLASTSVPTP	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TTLASTSVPTP

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of TTLASTSVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	886:896	TTLASTSVPTP	COP1	0.9636	More...