DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
TVGDDESVPTGY
Uniprot ID:
Q92834
Source protein:
X-linked retinitis pigmentosa GTPase regulator
Source gene:
RPGR
Class:
DEG_COP1_1
Location:
870:881
E3 ligase:
COP1
DEGRON score:
0.9541
ASA_SCORE:
86.7167
COIL:
0.8749
CONS_SCORE:
0.3013
DSS_SCORE:
0.6407
HELIX:
0.0583
FCONS_SCORE:
0.9819
RIG_SCORE:
0.6383
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RPGR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TVGDDESVPTGY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92834
X-linked retinitis pigmentosa GTPase regulator
DEG_COP1_1
870:881
TVGDDESVPTGY
COP1
0.9541
More...