DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 11395:11403

E3 ligase: COP1

DEGRON score: 0.8092

ASA_SCORE: 94.7667

COIL: 0.9137

CONS_SCORE: 0

DSS_SCORE: 0.5436

HELIX: 0.0159

FCONS_SCORE: 0

RIG_SCORE: 0.7468

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A11387D	TCGA-44-7669	LUAD	TCGA	TVSPDVPDM	DEG_COP1_1	0.1111
p.A11387D	DO229027	LICA	ICGC	TVSPDVPDM	DEG_COP1_1	0.1111
p.A11387D	DO229035	LICA	ICGC	TVSPDVPDM	DEG_COP1_1	0.1111
p.A11387D	DO25262	LUAD	ICGC	TVSPDVPDM	DEG_COP1_1	0.1111
p.D11399Y	TCGA-64-1676	LUAD	TCGA	TVSPDVPDM	DEG_COP1_1	0.6214
p.D11399Y	DO23629	LUAD	ICGC	TVSPDVPDM	DEG_COP1_1	0.6214
p.T11395N	TCGA-AZ-4315	COAD	TCGA	TVSPDVPDM	DEG_COP1_1	0.7055
p.T11395N	DO8842	COAD	ICGC	TVSPDVPDM	DEG_COP1_1	0.7055
p.V11404A	TCGA-B5-A11H	UCEC	TCGA	TVSPDVPDM	DEG_COP1_1	0.3056
p.V11404A	DO42825	UCEC	ICGC	TVSPDVPDM	DEG_COP1_1	0.3056
p.E11386D	TCGA-BR-6457	STAD	TCGA	TVSPDVPDM	DEG_COP1_1	0.0833
p.E11386D	DO38759	STAD	ICGC	TVSPDVPDM	DEG_COP1_1	0.0833
p.E11386D	SIDM00890	Melanoma	GDSC	TVSPDVPDM	DEG_COP1_1	0.0833
p.E11386D	ACH-000580	Skin Cancer	CCLE	TVSPDVPDM	DEG_COP1_1	0.0833
p.E11386D	C32	skin	COSMIC	TVSPDVPDM	DEG_COP1_1	0.0833
p.T11393I	TCGA-EI-6507	READ	TCGA	TVSPDVPDM	DEG_COP1_1	0.2778
p.T11393I	DO36675	READ	ICGC	TVSPDVPDM	DEG_COP1_1	0.2778
p.P11392S	TCGA-GN-A4U4	SKCM	TCGA	TVSPDVPDM	DEG_COP1_1	0.25
p.P11392S	DO51256	SKCM	ICGC	TVSPDVPDM	DEG_COP1_1	0.25
p.S11389L	TCGA-PK-A5HA	ACC	TCGA	TVSPDVPDM	DEG_COP1_1	0.1667
p.T11388S	DO228111	EOPC	ICGC	TVSPDVPDM	DEG_COP1_1	0.1389
p.F11391V	DO234400	ESAD	ICGC	TVSPDVPDM	DEG_COP1_1	0.2222
p.V11408I	DO220877	MELA	ICGC	TVSPDVPDM	DEG_COP1_1	0.1944
p.D11390N	DO222702	MELA	ICGC	TVSPDVPDM	DEG_COP1_1	0.1944
p.P11392L	DO229462	SKCA	ICGC	TVSPDVPDM	DEG_COP1_1	0.25
p.P11392T	DO231295	THCA	ICGC	TVSPDVPDM	DEG_COP1_1	0.25
p.P11398S	SIDM00516	Melanoma	GDSC	TVSPDVPDM	DEG_COP1_1	0.5641
p.P11398S	ACH-002166	Skin Cancer	CCLE	TVSPDVPDM	DEG_COP1_1	0.5641
p.P11398S	MZ7-mel	skin	COSMIC	TVSPDVPDM	DEG_COP1_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	11395:11403	TVSPDVPDM	COP1	0.8092	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TVSPDVPDM

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of TVSPDVPDM