DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 10409:10419

E3 ligase: COP1

DEGRON score: 0.5493

ASA_SCORE: 92.3

COIL: 0.8149

CONS_SCORE: 0

DSS_SCORE: 0.4247

HELIX: 0.0181

FCONS_SCORE: 0

RIG_SCORE: 0.7823

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V10405I	TCGA-06-6699	GBM	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405I	TCGA-85-A4CL	LUSC	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405I	DO233749	GACA	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405I	DO13893	GBM	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405I	DO229055	LICA	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405I	DO45454	LUSC	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405I	DO27819	MALY	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405I	DO52661	MALY	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405I	DO46897	RECA	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.T10411R	TCGA-33-4583	LUSC	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.6765
p.T10411R	DO27112	LUSC	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.6765
p.V10405D	TCGA-69-7980	LUAD	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.V10405D	DO23678	LUAD	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.2222
p.T10409R	TCGA-A4-8630	KIRP	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.7876
p.T10409R	DO44489	KIRP	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.7876
p.R10422Q	TCGA-AA-A010	COAD	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.25
p.R10422Q	SIDM00604	Oral Cavity Carcinoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.25
p.R10422Q	SIDM01609	Endometrial Carcinoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.25
p.R10422Q	ACH-000972	Endometrial/Uterine Cancer	CCLE	TVTSAYQVPSL	DEG_COP1_1	0.25
p.R10422Q	ACH-001542	Head and Neck Cancer	CCLE	TVTSAYQVPSL	DEG_COP1_1	0.25
p.R10422Q	KON	upper_aerodigestive_tract	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.25
p.T10399A	TCGA-B7-5816	STAD	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.0556
p.T10399A	DO38599	STAD	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.0556
p.G10408E	TCGA-DD-AAVY	LIHC	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.3056
p.G10408E	TCGA-FW-A3R5	SKCM	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.3056
p.G10408E	DO52284	LIHC	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.3056
p.G10408E	DO37406	SKCM	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.3056
p.G10408R	TCGA-EE-A20H	SKCM	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.3056
p.G10408R	TCGA-FW-A3R5	SKCM	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.3056
p.G10408R	DO37406	SKCM	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.3056
p.G10408R	DO37986	SKCM	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.3056
p.E10406K	TCGA-EE-A2MR	SKCM	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.25
p.E10406K	DO37819	SKCM	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.25
p.G10428D	TCGA-ER-A193	SKCM	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.0833
p.G10428D	DO47368	SKCM	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.0833
p.Q10415H	TCGA-HU-A4H3	STAD	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.647
p.Q10415H	DO47903	STAD	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.647
p.D10427N	TCGA-WE-A8ZO	SKCM	TCGA	TVTSAYQVPSL	DEG_COP1_1	0.1111
p.D10427N	DO219878	SKCA	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.1111
p.D10427N	DO51286	SKCM	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.1111
p.E10403V	DO228934	LICA	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.1667
p.R10400K	DO32831	PACA	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.0833
p.S10412I	DO46844	RECA	ICGC	TVTSAYQVPSL	DEG_COP1_1	0.7341
p.E10403D	SIDM01117	Small Cell Lung Carcinoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.1667
p.E10403D	ACH-002176	Lung Cancer	CCLE	TVTSAYQVPSL	DEG_COP1_1	0.1667
p.E10403D	NCI-H748	lung	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.1667
p.S10404R	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	SIDM00002	Neuroblastoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	SIDM00324	Neuroblastoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	SIDM00368	Small Cell Lung Carcinoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	SIDM01449	Pancreatic Carcinoma	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	SIDM00959	Acute Myeloid Leukemia	GDSC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	NBsusSR	autonomic_ganglia	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	HCC-56	large_intestine	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	TGW	autonomic_ganglia	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	TE-15	oesophagus	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	TE-6	oesophagus	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.S10404R	SBC-5	lung	COSMIC	TVTSAYQVPSL	DEG_COP1_1	0.1944
p.T10402S	ACH-001664	Gastric Cancer	CCLE	TVTSAYQVPSL	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TVTSAYQVPSL

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of TVTSAYQVPSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	10409:10419	TVTSAYQVPSL	COP1	0.5493	More...