DegronMD

Uniprot ID: P09874

Source protein: Poly [ADP-ribose] polymerase 1

Source gene: PARP1

Class: DEG_SCF_FBW7_1

Location: 365:372

E3 ligase: FBXW7

DEGRON score: 0.8146

ASA_SCORE: 75.125

COIL: 0.905

CONS_SCORE: 0.237

DSS_SCORE: 0.5426

HELIX: 0.0596

FCONS_SCORE: 0.8164

RIG_SCORE: 0.6093

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E360V	TCGA-B1-A657	KIRP	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.1944
p.E360V	DO51552	KIRP	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.1944
p.P369L	TCGA-BH-A0HF	BRCA	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.7582
p.P369L	TCGA-VN-A88Q	PRAD	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.7582
p.P369L	DO1749	BRCA	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.7582
p.P369L	DO49862	PRAD	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.7582
p.V365M	TCGA-CD-8536	STAD	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.6097
p.V365M	DO47827	STAD	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.6097
p.S375L	TCGA-D3-A8GS	SKCM	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.6944
p.S375L	DO51248	SKCM	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.6944
p.P371L	TCGA-FR-A726	SKCM	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.6471
p.P371L	DO48665	SKCM	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.6471
p.A363T	TCGA-MH-A854	KIRP	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.2778
p.A363T	DO49773	KIRP	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.2778
p.T368M	TCGA-X8-AAAR	ESCA	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.8534
p.T368M	SIDM00516	Melanoma	GDSC	VAATPPPS	DEG_SCF_FBW7_1	0.8534
p.T368M	ACH-002166	Skin Cancer	CCLE	VAATPPPS	DEG_SCF_FBW7_1	0.8534
p.T368M	MZ7-mel	skin	COSMIC	VAATPPPS	DEG_SCF_FBW7_1	0.8534
p.T368K	DO229031	LICA	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.8417
p.P358L	SIDM01281	Colorectal Carcinoma	GDSC	VAATPPPS	DEG_SCF_FBW7_1	0.1389
p.R355G	SIDM01102	Non-Cancerous	GDSC	VAATPPPS	DEG_SCF_FBW7_1	0.0556
p.R355G	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	VAATPPPS	DEG_SCF_FBW7_1	0.0556
p.A367D	ACH-000595	Brain Cancer	CCLE	VAATPPPS	DEG_SCF_FBW7_1	0.6682

Drug responses associated with PARP1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Olaparib	28.9497
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Veliparib	34.5742
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Rucaparib	21.8059
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Talazoparib	15.9387
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	PARP_9495	10.6541
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	PARP_0108	0.2976
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	PARP_9482	0.5389
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Olaparib	33.499
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Olaparib	13.838
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Niraparib	4.2281
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E12G (No)	GDSC	Talazoparib	1.4429
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	Olaparib	13.8814
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	Veliparib	15.3598
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	Rucaparib	27.6505
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	Talazoparib	1.0245
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	PARP_9495	3.5931
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	PARP_0108	0.1139
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	PARP_9482	0.0405
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	Olaparib	16.3944
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	Olaparib	23.901
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	Niraparib	9.2245
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R355G (Yes)	GDSC	Talazoparib	1.572
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Olaparib	21.1217
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Veliparib	48.3284
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Rucaparib	37.6205
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Talazoparib	1.1623
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	PARP_9495	9.4335
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	PARP_0108	0.1354
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	PARP_9482	0.1094
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Olaparib	70.1044
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Olaparib	17.443
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Niraparib	16.312
SIDM00688	DLBC\|B_cell_lymphoma	p.H909N (No)	GDSC	Talazoparib	0.5012
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Olaparib	139.3627
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Veliparib	153.304
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Rucaparib	128.3722
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Talazoparib	51.1424
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	PARP_9495	10.3456
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	PARP_0108	54.5668
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	PARP_9482	47.6663
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Olaparib	78.7893
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Olaparib	302.53
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Niraparib	141.68
SIDM01045	UCEC\|endometrium	p.L641fs*12 (No)	GDSC	Talazoparib	339.57
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Olaparib	45.0438
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Veliparib	18.6869
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Rucaparib	45.0971
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Talazoparib	36.9737
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	PARP_9495	6.5918
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	PARP_0108	8.5078
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	PARP_9482	6.6211
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Olaparib	67.7565
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Olaparib	26.938
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Niraparib	68.583
SIDM01036	MM\|haematopoietic_neoplasm_other	p.M411I (No)	GDSC	Talazoparib	51.856
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Olaparib	51.806
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Veliparib	96.1916
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Rucaparib	109.2261
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Talazoparib	2.8201
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	PARP_9495	6.8261
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	PARP_0108	1.2121
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	PARP_9482	0.7719
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Olaparib	18.7439
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Olaparib	40.03
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Niraparib	50.73
SIDM00214	COREAD\|large_intestine	p.S507fs*17 (No)	GDSC	Talazoparib	10.383
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Olaparib	8.1964
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Veliparib	31.099
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Rucaparib	12.794
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Talazoparib	3.4679
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	PARP_9495	24.3685
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	PARP_0108	0.4213
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	PARP_9482	0.1812
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Olaparib	41.1309
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Olaparib	8.3939
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Niraparib	6.5442
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A178V (No)	GDSC	Talazoparib	0.92
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Olaparib	51.806
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Veliparib	96.1916
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Rucaparib	109.2261
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Talazoparib	2.8201
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	PARP_9495	6.8261
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	PARP_0108	1.2121
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	PARP_9482	0.7719
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Olaparib	18.7439
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Olaparib	40.03
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Niraparib	50.73
SIDM00214	COREAD\|large_intestine	p.M604I (No)	GDSC	Talazoparib	10.383
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Olaparib	27.6421
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Veliparib	36.3225
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Rucaparib	39.2539
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Talazoparib	5.0437
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	PARP_9495	3.098
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	PARP_0108	0.6637
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	PARP_9482	0.5832
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Olaparib	46.1995
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Olaparib	118.27
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Niraparib	38.483
SIDM01090	COREAD\|large_intestine	p.T910A (No)	GDSC	Talazoparib	45.622
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Olaparib	84.5948
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Veliparib	73.1547
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Rucaparib	105.2562
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Talazoparib	7.1563
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	PARP_9495	3.9662
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	PARP_0108	0.5484
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	PARP_9482	0.152
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Olaparib	32.9291
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Olaparib	182.89
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Niraparib	91.197
SIDM01106	SKCM\|melanoma	p.P850L (No)	GDSC	Talazoparib	113.44
SIDM00516	SKCM\|melanoma	p.T368M (Yes)	GDSC	Olaparib	67.1509
SIDM00516	SKCM\|melanoma	p.T368M (Yes)	GDSC	Veliparib	56.4292
SIDM00516	SKCM\|melanoma	p.T368M (Yes)	GDSC	Rucaparib	100.6875
SIDM00516	SKCM\|melanoma	p.T368M (Yes)	GDSC	Talazoparib	17.6261
SIDM00516	SKCM\|melanoma	p.T368M (Yes)	GDSC	PARP_9495	31.8819
SIDM00516	SKCM\|melanoma	p.T368M (Yes)	GDSC	PARP_0108	2.3961
SIDM00516	SKCM\|melanoma	p.T368M (Yes)	GDSC	PARP_9482	3.6494
SIDM00516	SKCM\|melanoma	p.T368M (Yes)	GDSC	Olaparib	104.1646
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Olaparib	144.1141
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Veliparib	119.3164
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Rucaparib	166.6094
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Talazoparib	104.3563
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	PARP_9495	8.926
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	PARP_0108	5.0618
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	PARP_9482	3.7524
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Olaparib	206.5212
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Olaparib	57.699
SIDM00945	COREAD\|large_intestine	p.E297* (No)	GDSC	Niraparib	181.63
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Olaparib	69.4471
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Veliparib	69.2845
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Rucaparib	41.005
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Talazoparib	12.7806
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	PARP_9495	4.0833
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	PARP_0108	5.4511
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	PARP_9482	4.2406
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Olaparib	72.3317
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Olaparib	164.42
SIDM00252	UNCLASSIFIED\|biliary_tract	p.Y634C (No)	GDSC	Talazoparib	130.87
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Olaparib	69.4471
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Veliparib	69.2845
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Rucaparib	41.005
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Talazoparib	12.7806
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	PARP_9495	4.0833
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	PARP_0108	5.4511
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	PARP_9482	4.2406
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Olaparib	72.3317
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Olaparib	164.42
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R117H (No)	GDSC	Talazoparib	130.87
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Olaparib	18.5867
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Veliparib	31.7423
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Rucaparib	35.6363
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Talazoparib	68.8912
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	PARP_9495	5.1378
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	PARP_0108	1.8342
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	PARP_9482	1.712
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Olaparib	57.5172
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Olaparib	127.23
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Niraparib	94.18
SIDM01019	LAML\|acute_myeloid_leukaemia	p.N450S (No)	GDSC	Talazoparib	127.41
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Olaparib	8.6788
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Veliparib	9.893
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Rucaparib	11.1279
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Talazoparib	37.0512
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	PARP_9495	5.6984
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	PARP_0108	5.8627
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	PARP_9482	4.5774
SIDM00404	DLBC\|B_cell_lymphoma	p.Y1001F (No)	GDSC	Olaparib	18.5833
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (Yes)	GDSC	Olaparib	27.8749
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (Yes)	GDSC	Veliparib	53.2094
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (Yes)	GDSC	Rucaparib	13.2125
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (Yes)	GDSC	Talazoparib	3.1123
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (Yes)	GDSC	PARP_9495	2.6107
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (Yes)	GDSC	PARP_0108	0.1361
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (Yes)	GDSC	PARP_9482	0.2891
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D354A (Yes)	GDSC	Olaparib	24.282
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Olaparib	98.1894
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Veliparib	94.2574
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Rucaparib	22.4836
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Talazoparib	3.5552
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	PARP_9495	13.2069
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	PARP_0108	1.6424
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	PARP_9482	0.2739
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Olaparib	61.6087
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Olaparib	52.672
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Niraparib	74.32
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L964Q (No)	GDSC	Talazoparib	8.2491
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	Talazoparib	219.8695
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	PARP_0108	59.0125
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	PARP_9482	52.5477
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	Olaparib	146.0198
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	Olaparib	192.55
SIDM00217	COREAD\|large_intestine	p.I585V (No)	GDSC	Niraparib	298.82
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	Talazoparib	219.8695
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	PARP_0108	59.0125
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	PARP_9482	52.5477
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	Olaparib	146.0198
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	Olaparib	192.55
SIDM00217	COREAD\|large_intestine	p.G565R (No)	GDSC	Niraparib	298.82
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	Talazoparib	219.8695
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	PARP_0108	59.0125
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	PARP_9482	52.5477
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	Olaparib	146.0198
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	Olaparib	192.55
SIDM00217	COREAD\|large_intestine	p.S507N (No)	GDSC	Niraparib	298.82
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Olaparib	7.4285
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Veliparib	15.3437
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Rucaparib	20.0131
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	PARP_9495	9.2762
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	PARP_0108	0.1525
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	PARP_9482	0.0782
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Olaparib	32.234
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Niraparib	8.5458
SIDM00243	UNCLASSIFIED\|testis	p.E251K (No)	GDSC	Talazoparib	35.736
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Olaparib	62.9117
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Veliparib	65.7692
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Rucaparib	69.991
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Talazoparib	23.0859
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	PARP_9495	2.9619
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	PARP_0108	2.2915
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	PARP_9482	3.2072
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Olaparib	95.5663
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Olaparib	136.22
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Niraparib	135.17
SIDM00082	SKCM\|melanoma	p.P882L (No)	GDSC	Talazoparib	136.69
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Olaparib	90.44
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Veliparib	53.6085
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Rucaparib	13.333
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Talazoparib	61.671
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	PARP_9495	43.0997
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	PARP_0108	14.6944
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	PARP_9482	13.8673
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Olaparib	317.8826
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Olaparib	155.52
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Niraparib	41.985
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.K59N (No)	GDSC	Talazoparib	132.13
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Olaparib	11.4613
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Veliparib	7.8437
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Rucaparib	7.7732
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Talazoparib	4.9053
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	PARP_9495	3.8343
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	PARP_0108	2.0604
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	PARP_9482	2.0053
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Olaparib	35.9394
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Olaparib	130.39
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Niraparib	365.31
SIDM00596	UCEC\|endometrium	p.E772K (No)	GDSC	Talazoparib	88.499
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Olaparib	129.7192
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Veliparib	136.8174
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Rucaparib	95.4738
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Talazoparib	65.4633
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	PARP_9495	12.7941
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	PARP_0108	4.4096
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	PARP_9482	5.5348
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Olaparib	254.0929
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Olaparib	184.75
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Niraparib	48.663
SIDM00282	COREAD\|large_intestine	p.K230N (No)	GDSC	Talazoparib	19.058
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Olaparib	83.2592
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Veliparib	81.0085
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Rucaparib	61.3006
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Talazoparib	6.3291
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	PARP_9495	28.206
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	PARP_0108	37.1484
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	PARP_9482	31.4291
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Olaparib	136.3961
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Olaparib	86.73
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Niraparib	185.98
SIDM00150	COREAD\|large_intestine	p.E602Q (No)	GDSC	Talazoparib	11.992
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Olaparib	36.5278
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Veliparib	93.9636
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Rucaparib	15.8752
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Talazoparib	19.0318
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	PARP_9495	29.2395
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	PARP_0108	2.1563
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	PARP_9482	2.041
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Olaparib	42.4012
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.L1013M (No)	GDSC	Niraparib	168.71
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Olaparib	116.1198
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Veliparib	86.8828
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Rucaparib	39.2988
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Talazoparib	0.4592
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	PARP_9495	4.4051
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	PARP_0108	0.252
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	PARP_9482	0.1025
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Olaparib	23.2666
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Olaparib	23.375
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Niraparib	28.473
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.S785N (No)	GDSC	Talazoparib	0.8966
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Olaparib	47.8939
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Veliparib	47.9549
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Rucaparib	65.383
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Talazoparib	4.2808
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	PARP_9495	1.8509
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	PARP_0108	0.6792
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	PARP_9482	0.6251
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Olaparib	16.8474
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Olaparib	80.529
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Niraparib	24.426
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.G913fs*4 (No)	GDSC	Talazoparib	35.805
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Olaparib	27.6421
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Veliparib	36.3225
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Rucaparib	39.2539
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Talazoparib	5.0437
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	PARP_9495	3.098
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	PARP_0108	0.6637
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	PARP_9482	0.5832
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Olaparib	46.1995
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Olaparib	118.27
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Niraparib	38.483
SIDM01090	COREAD\|large_intestine	p.K418fs*2 (No)	GDSC	Talazoparib	45.622
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Olaparib	67.5525
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Veliparib	70.5532
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Rucaparib	45.0857
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Talazoparib	14.4677
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	PARP_9495	21.3599
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	PARP_0108	4.1614
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	PARP_9482	3.2333
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Olaparib	32.4328
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Olaparib	121.5
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Niraparib	186.22
SIDM00487	COREAD\|large_intestine	p.E840A (No)	GDSC	Talazoparib	23.157
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (Yes)	GDSC	Talazoparib	219.8695
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (Yes)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (Yes)	GDSC	PARP_0108	59.0125
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (Yes)	GDSC	PARP_9482	52.5477
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (Yes)	GDSC	Olaparib	146.0198
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (Yes)	GDSC	Olaparib	192.55
SIDM00217	COREAD\|large_intestine	p.P359fs*22 (Yes)	GDSC	Niraparib	298.82
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Olaparib	26.1742
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Veliparib	35.1199
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Rucaparib	44.1009
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Talazoparib	12.5246
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	PARP_9495	5.6367
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	PARP_0108	0.6846
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	PARP_9482	0.6538
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Olaparib	40.0004
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Olaparib	23.772
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Niraparib	6.3068
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S507fs*17 (No)	GDSC	Talazoparib	1.5657
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Olaparib	149.7471
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Veliparib	151.3402
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Rucaparib	149.457
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Talazoparib	19.3772
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	PARP_9495	6.8267
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	PARP_0108	3.5898
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	PARP_9482	5.5908
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Olaparib	122.944
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Olaparib	268.93
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Niraparib	239.92
SIDM00114	MESO\|mesothelioma	p.S542F (No)	GDSC	Talazoparib	70.468
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Olaparib	149.7471
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Veliparib	151.3402
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Rucaparib	149.457
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Talazoparib	19.3772
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	PARP_9495	6.8267
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	PARP_0108	3.5898
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	PARP_9482	5.5908
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Olaparib	122.944
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Olaparib	268.93
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Niraparib	239.92
SIDM00114	MESO\|mesothelioma	p.K131N (No)	GDSC	Talazoparib	70.468
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	4.4229
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Veliparib	16.4982
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Rucaparib	2.1441
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Talazoparib	0.0368
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	PARP_9495	1.1012
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	PARP_0108	0.0297
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	PARP_9482	0.007
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	4.0485
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	3.5001
SIDM00290	STAD\|stomach	p.V283L (No)	GDSC	Niraparib	94.884
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Olaparib	6.4882
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Veliparib	44.5219
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Rucaparib	9.2447
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Talazoparib	3.7021
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	PARP_9495	8.613
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	PARP_0108	0.5938
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	PARP_9482	0.7771
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Olaparib	23.2173
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Olaparib	70.474
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Niraparib	84.184
SIDM00807	BLCA\|bladder	p.P125fs*45 (No)	GDSC	Talazoparib	9.1241
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Olaparib	8.0181
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Veliparib	45.8528
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Rucaparib	4.1629
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Talazoparib	0.1455
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	PARP_9495	2.5711
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	PARP_0108	0.0267
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	PARP_9482	0.0123
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A502V (No)	GDSC	Olaparib	16.3352
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Olaparib	96.5067
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Veliparib	96.6953
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Rucaparib	18.2648
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Talazoparib	7.2154
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	PARP_9495	2.5473
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	PARP_0108	2.6126
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	PARP_9482	1.3137
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Olaparib	22.3609
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Olaparib	265.12
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Niraparib	327.12
SIDM00465	OV\|ovary	p.A685T (No)	GDSC	Talazoparib	44.606
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Olaparib	26.7778
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Veliparib	25.8986
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Rucaparib	35.5505
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Talazoparib	21.9763
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	PARP_9495	18.3154
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	PARP_0108	1.1372
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	PARP_9482	1.6602
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Olaparib	66.4755
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Olaparib	16.637
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Niraparib	20.122
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.V139A (No)	GDSC	Talazoparib	6.4805
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	10.4611
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Veliparib	56.2188
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Rucaparib	111.6994
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Talazoparib	90.7763
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	PARP_9495	32.2639
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	PARP_0108	9.6603
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	PARP_9482	7.6581
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	65.3902
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Olaparib	8.6246
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Niraparib	174.15
SIDM01146	STAD\|stomach	p.V283L (No)	GDSC	Talazoparib	11.636
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Olaparib	10.4611
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Veliparib	56.2188
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Rucaparib	111.6994
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Talazoparib	90.7763
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	PARP_9495	32.2639
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	PARP_0108	9.6603
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	PARP_9482	7.6581
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Olaparib	65.3902
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Olaparib	8.6246
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Niraparib	174.15
SIDM01146	STAD\|stomach	p.K221N (No)	GDSC	Talazoparib	11.636
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Olaparib	58.7209
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Veliparib	41.3761
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Rucaparib	35.9668
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Talazoparib	1.4584
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	PARP_9495	1.7049
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	PARP_0108	0.3277
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	PARP_9482	0.1251
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Olaparib	47.9735
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Olaparib	86.05
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Niraparib	26.374
SIDM00837	COREAD\|large_intestine	p.N440S (No)	GDSC	Talazoparib	4.9819
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Olaparib	5.1446
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Veliparib	30.0106
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Rucaparib	25.1956
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Talazoparib	5.9816
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	PARP_9495	6.4904
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	PARP_0108	1.0445
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	PARP_9482	0.6373
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Olaparib	23.0392
SIDM00238	OV\|ovary	p.Y570C (No)	GDSC	Niraparib	140.78
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Olaparib	38.4836
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Veliparib	86.9327
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Rucaparib	69.6498
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Talazoparib	189.4873
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	PARP_9495	47.2701
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	PARP_0108	47.3718
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	PARP_9482	46.9813
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Olaparib	43.1791
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Olaparib	52.681
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Niraparib	107.1
SIDM00920	BRCA\|breast	p.S714N (No)	GDSC	Talazoparib	52.448

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09874	Poly [ADP-ribose] polymerase 1	DEG_SCF_FBW7_1	365:372	VAATPPPS	FBXW7	0.8146	More...
P98164	Low-density lipoprotein receptor-related protein 2	DEG_SCF_FBW7_1	4609:4616	VAATPPPS	FBXW7	0.9659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VAATPPPS

Degron related mutations and impact score

Drug responses associated with PARP1 mutations

All proteins holding degron of VAATPPPS