DegronMD

Uniprot ID: P98164

Source protein: Low-density lipoprotein receptor-related protein 2

Source gene: LRP2

Class: DEG_SCF_FBW7_1

Location: 4609:4616

E3 ligase: FBXW7

DEGRON score: 0.9659

ASA_SCORE: 91.425

COIL: 0.8991

CONS_SCORE: 0.445

DSS_SCORE: 0.7632

HELIX: 0.0879

FCONS_SCORE: 1.1533

RIG_SCORE: 0.5456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4614S	TCGA-38-4632	LUAD	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.5641
p.P4614S	DO23858	LUAD	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.5641
p.A4611V	TCGA-AP-A056	UCEC	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.5825
p.A4611V	TCGA-B5-A3FA	UCEC	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.5825
p.A4611V	TCGA-BS-A0UF	UCEC	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.5825
p.A4611V	DO52402	UCEC	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.5825
p.A4611V	DO41488	UCEC	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.5825
p.A4611V	DO43971	UCEC	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.5825
p.E4604G	TCGA-B8-A54D	KIRC	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.1944
p.E4604G	DO49730	KIRC	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.1944
p.S4618L	TCGA-EB-A41A	SKCM	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.2778
p.S4618L	DO221128	MALY	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.2778
p.S4618L	DO222527	MELA	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.2778
p.S4618L	DO37429	SKCM	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.2778
p.S4618L	ACH-001656	Leukemia	CCLE	VAATPPPS	DEG_SCF_FBW7_1	0.2778
p.P4620S	TCGA-FW-A3R5	SKCM	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.2222
p.P4620S	DO37406	SKCM	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.2222
p.E4604K	TCGA-WS-AB45	COAD	TCGA	VAATPPPS	DEG_SCF_FBW7_1	0.1944
p.E4604K	DO51734	COAD	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.1944
p.E4602V	DO230311	COCA	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.1389
p.P4625L	DO220886	MELA	ICGC	VAATPPPS	DEG_SCF_FBW7_1	0.0833
p.A4599V	SIDM00193	Colorectal Carcinoma	GDSC	VAATPPPS	DEG_SCF_FBW7_1	0.0556
p.A4599V	ACH-000991	Colon/Colorectal Cancer	CCLE	VAATPPPS	DEG_SCF_FBW7_1	0.0556
p.A4599V	SNU-81	large_intestine	COSMIC	VAATPPPS	DEG_SCF_FBW7_1	0.0556
p.P4620L	SIDM00511	Small Cell Lung Carcinoma	GDSC	VAATPPPS	DEG_SCF_FBW7_1	0.2222
p.P4620L	ACH-000257	Lung Cancer	CCLE	VAATPPPS	DEG_SCF_FBW7_1	0.2222
p.P4620L	COR-L279	lung	COSMIC	VAATPPPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09874	Poly [ADP-ribose] polymerase 1	DEG_SCF_FBW7_1	365:372	VAATPPPS	FBXW7	0.8146	More...
P98164	Low-density lipoprotein receptor-related protein 2	DEG_SCF_FBW7_1	4609:4616	VAATPPPS	FBXW7	0.9659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VAATPPPS

Degron related mutations and impact score

Drug responses associated with LRP2 mutations

All proteins holding degron of VAATPPPS