DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VATPQVS
Uniprot ID:
Q96JG8
Source protein:
Melanoma-associated antigen D4
Source gene:
MAGED4; MAGED4B
Class:
DEG_SCF_FBW7_1
Location:
137:143
E3 ligase:
FBXW7
DEGRON score:
0.9585
ASA_SCORE:
78.4143
COIL:
0.8313
CONS_SCORE:
0.3982
DSS_SCORE:
0.5856
HELIX:
0.0931
FCONS_SCORE:
1.0113
RIG_SCORE:
0.6532
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MAGED4; MAGED4B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VATPQVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JG8
Melanoma-associated antigen D4
DEG_SCF_FBW7_1
137:143
VATPQVS
FBXW7
0.9585
More...