DegronMD

Uniprot ID: P49795

Source protein: Regulator of G-protein signaling 19

Source gene: RGS19

Class: DEG_SCF_FBW7_2

Location: 75:82

E3 ligase: FBXW7

DEGRON score: 0.7261

ASA_SCORE: 62.0875

COIL: 0.7006

CONS_SCORE: 0.5096

DSS_SCORE: 0.3589

HELIX: 0.2759

FCONS_SCORE: 1.0315

RIG_SCORE: 0.6946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E83K	TCGA-W3-A828	SKCM	TCGA	VCATPSPE	DEG_SCF_FBW7_2	0.3056
p.E83K	DO51273	SKCM	ICGC	VCATPSPE	DEG_SCF_FBW7_2	0.3056
p.E83G	DO234462	ESAD	ICGC	VCATPSPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49795	Regulator of G-protein signaling 19	DEG_SCF_FBW7_2	75:82	VCATPSPE	FBXW7	0.7261	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons