DegronMD

Uniprot ID: A8MUX0

Source protein: Keratin-associated protein 16-1

Source gene: KRTAP16-1

Class: DEG_SCF_FBW7_1

Location: 232:239

E3 ligase: FBXW7

DEGRON score: 0.8392

ASA_SCORE: 78.725

COIL: 0.8823

CONS_SCORE: 0.5384

DSS_SCORE: 0.0001

HELIX: 0.0188

FCONS_SCORE: 0.7022

RIG_SCORE: 0.7777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S243G	DO222990	BTCA	ICGC	VCPTPTCS	DEG_SCF_FBW7_1	0.2222
p.S243G	DO230550	LUSC	ICGC	VCPTPTCS	DEG_SCF_FBW7_1	0.2222
p.C238W	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	VCPTPTCS	DEG_SCF_FBW7_1	0.5889
p.C238W	ACH-000823	Esophageal Cancer	CCLE	VCPTPTCS	DEG_SCF_FBW7_1	0.5889
p.C238W	KYSE-140	oesophagus	COSMIC	VCPTPTCS	DEG_SCF_FBW7_1	0.5889
p.P234S	SIDM00844	Burkitt's Lymphoma	GDSC	VCPTPTCS	DEG_SCF_FBW7_1	0.5641
p.T241P	HCC2998	large_intestine	COSMIC	VCPTPTCS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MUX0	Keratin-associated protein 16-1	DEG_SCF_FBW7_1	232:239	VCPTPTCS	FBXW7	0.8392	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons