DegronMD

Uniprot ID: Q9H2S9

Source protein: Zinc finger protein Eos

Source gene: IKZF4

Class: LIG_APCC_ABBA_1

Location: 101:106

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9622

ASA_SCORE: 77.8

COIL: 0.4145

CONS_SCORE: 0.6379

DSS_SCORE: 0.4814

HELIX: 0.0387

FCONS_SCORE: 1.1109

RIG_SCORE: 0.7202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L94R	TCGA-AP-A0LM	UCEC	TCGA	VEMYSD	LIG_APCC_ABBA_1	0.1389
p.G98A	DO229016	COCA	ICGC	VEMYSD	LIG_APCC_ABBA_1	0.25
p.P104S	DO233889	GACA	ICGC	VEMYSD	LIG_APCC_ABBA_1	0.6752
p.P104T	DO14398	HNSC	ICGC	VEMYSD	LIG_APCC_ABBA_1	0.7031
p.C94F	DO229025	LICA	ICGC	VEMYSD	LIG_APCC_ABBA_1	0.1389
p.R108W	DO51407	PRAD	ICGC	VEMYSD	LIG_APCC_ABBA_1	0.2778
p.R108Q	DO38400	STAD	ICGC	VEMYSD	LIG_APCC_ABBA_1	0.2778
p.R108Q	DO41871	UCEC	ICGC	VEMYSD	LIG_APCC_ABBA_1	0.2778
p.G106S	DO47911	STAD	ICGC	VEMYSD	LIG_APCC_ABBA_1	0.6993
p.G105E	ACH-000899	Skin Cancer	CCLE	VEMYSD	LIG_APCC_ABBA_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2S9	Zinc finger protein Eos	LIG_APCC_ABBA_1	101:106	VEMYSD	APC,CDC20,FZR1	0.9622	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons