DegronMD

Uniprot ID: Q9NVH2

Source protein: Integrator complex subunit 7

Source gene: INTS7

Class: LIG_APCC_ABBA_1

Location: 881:886

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8743

ASA_SCORE: 79.9333

COIL: 0.561

CONS_SCORE: 0.4222

DSS_SCORE: 0.3984

HELIX: 0.0262

FCONS_SCORE: 1.0287

RIG_SCORE: 0.7837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E876Q	TCGA-5L-AAT1	BRCA	TCGA	VEPHND	LIG_APCC_ABBA_1	0.1944
p.Q891R	TCGA-D1-A167	UCEC	TCGA	VEPHND	LIG_APCC_ABBA_1	0.1944
p.I896V	DO49095	COAD	ICGC	VEPHND	LIG_APCC_ABBA_1	0.0556
p.L879I	DO229022	LICA	ICGC	VEPHND	LIG_APCC_ABBA_1	0.2778
p.L873V	DO23246	LINC	ICGC	VEPHND	LIG_APCC_ABBA_1	0.1111
p.V890M	DO50803	LIRI	ICGC	VEPHND	LIG_APCC_ABBA_1	0.2222
p.A893V	DO51407	PRAD	ICGC	VEPHND	LIG_APCC_ABBA_1	0.1389
p.L879F	DO229446	SKCA	ICGC	VEPHND	LIG_APCC_ABBA_1	0.2778
p.Q871R	DO40978	UCEC	ICGC	VEPHND	LIG_APCC_ABBA_1	0.0556
p.E887K	DO43186	UCEC	ICGC	VEPHND	LIG_APCC_ABBA_1	0.3056
p.H882R	SNU-1040	large_intestine	COSMIC	VEPHND	LIG_APCC_ABBA_1	0.8244
p.T887K	D-336MG	central_nervous_system	COSMIC	VEPHND	LIG_APCC_ABBA_1	0.3056
p.H888R	SNU-1040	large_intestine	COSMIC	VEPHND	LIG_APCC_ABBA_1	0.2778
p.T881K	D-336MG	central_nervous_system	COSMIC	VEPHND	LIG_APCC_ABBA_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVH2	Integrator complex subunit 7	LIG_APCC_ABBA_1	881:886	VEPHND	APC,CDC20,FZR1	0.8743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons