DegronMD

Uniprot ID: Q14244

Source protein: Ensconsin

Source gene: MAP7

Class: DEG_SCF_FBW7_2

Location: 670:677

E3 ligase: FBXW7

DEGRON score: 0.5497

ASA_SCORE: 92.4125

COIL: 0.8373

CONS_SCORE: 0.3278

DSS_SCORE: 0.6855

HELIX: 0.118

FCONS_SCORE: 0.9106

RIG_SCORE: 0.7003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G672E	TCGA-BF-A3DM	SKCM	TCGA	VESTPDLE	DEG_SCF_FBW7_2	0.7199
p.G672E	DO48667	SKCM	ICGC	VESTPDLE	DEG_SCF_FBW7_2	0.7199
p.P671S	TCGA-D5-6928	COAD	TCGA	VESTPDLE	DEG_SCF_FBW7_2	0.6752
p.P671S	DO7776	COAD	ICGC	VESTPDLE	DEG_SCF_FBW7_2	0.6752
p.G674R	DO218861	SKCA	ICGC	VESTPDLE	DEG_SCF_FBW7_2	0.7568
p.A663T	DO38404	STAD	ICGC	VESTPDLE	DEG_SCF_FBW7_2	0.1389
p.A663T	DO229253	THCA	ICGC	VESTPDLE	DEG_SCF_FBW7_2	0.1389
p.G661E	SIDM00632	Non-Cancerous	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.0833
p.G661E	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	VESTPDLE	DEG_SCF_FBW7_2	0.0833
p.P679L	SIDM00633	Breast Carcinoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.2778
p.P679L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.2778
p.P679L	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.2778
p.P679L	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.2778
p.T676R	SIDM00633	Breast Carcinoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.7876
p.T676R	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.7876
p.T676R	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.7876
p.T676R	SIDM00863	Burkitt's Lymphoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.7876
p.T676R	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	VESTPDLE	DEG_SCF_FBW7_2	0.7876
p.D675E	ACH-000985	Colon/Colorectal Cancer	CCLE	VESTPDLE	DEG_SCF_FBW7_2	0.5647
p.D675E	LS-411N	large_intestine	COSMIC	VESTPDLE	DEG_SCF_FBW7_2	0.5647
p.E678Q	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	VESTPDLE	DEG_SCF_FBW7_2	0.3056
p.D660E	LS-411N	large_intestine	COSMIC	VESTPDLE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14244	Ensconsin	DEG_SCF_FBW7_2	670:677	VESTPDLE	FBXW7	0.5497	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESTPDLE

Degron related mutations and impact score

Drug responses associated with MAP7 mutations

All proteins holding degron of VESTPDLE