DegronMD

Uniprot ID: O14798

Source protein: Tumor necrosis factor receptor superfamily member 10C

Source gene: TNFRSF10C

Class: DEG_SCF_FBW7_2

Location: 159:165

E3 ligase: FBXW7

DEGRON score: 0.9326

ASA_SCORE: 80.7

COIL: 0.7639

CONS_SCORE: 0.543

DSS_SCORE: 0.6261

HELIX: 0.1731

FCONS_SCORE: 0.97

RIG_SCORE: 0.7329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N156S	TCGA-AD-6895	COAD	TCGA	VETPAAE	DEG_SCF_FBW7_2	0.25
p.F153C	TCGA-D1-A103	UCEC	TCGA	VETPAAE	DEG_SCF_FBW7_2	0.1667
p.P172L	TCGA-FW-A3R5	SKCM	TCGA	VETPAAE	DEG_SCF_FBW7_2	0.1389
p.V159M	SIDM02039	Colorectal Carcinoma	GDSC	VETPAAE	DEG_SCF_FBW7_2	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14798	Tumor necrosis factor receptor superfamily member 10C	DEG_SCF_FBW7_2	159:165	VETPAAE	FBXW7	0.9326	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons