DegronMD

Uniprot ID: Q9BXJ9

Source protein: N-alpha-acetyltransferase 15, NatA auxiliary subunit

Source gene: NAA15

Class: DEG_SCF_FBW7_2

Location: 650:656

E3 ligase: FBXW7

DEGRON score: 0.7414

ASA_SCORE: 55.4571

COIL: 0.5267

CONS_SCORE: 0.4752

DSS_SCORE: 0.2309

HELIX: 0.4543

FCONS_SCORE: 1.2531

RIG_SCORE: 0.8164

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K665N	TCGA-F5-6814	READ	TCGA	VETPLEE	DEG_SCF_FBW7_2	0.5278
p.K665N	DO36556	READ	ICGC	VETPLEE	DEG_SCF_FBW7_2	0.5278
p.E651K	TCGA-IR-A3LH	CESC	TCGA	VETPLEE	DEG_SCF_FBW7_2	0.591
p.E651K	DO44381	CESC	ICGC	VETPLEE	DEG_SCF_FBW7_2	0.591
p.E651K	SIDM00333	Endometrial Carcinoma	GDSC	VETPLEE	DEG_SCF_FBW7_2	0.591
p.E651K	ACH-000988	Endometrial/Uterine Cancer	CCLE	VETPLEE	DEG_SCF_FBW7_2	0.591
p.E651K	MFE-319	endometrium	COSMIC	VETPLEE	DEG_SCF_FBW7_2	0.591
p.E656K	TCGA-IR-A3LH	CESC	TCGA	VETPLEE	DEG_SCF_FBW7_2	0.7022
p.E656K	DO44381	CESC	ICGC	VETPLEE	DEG_SCF_FBW7_2	0.7022
p.P663L	DO42673	UCEC	ICGC	VETPLEE	DEG_SCF_FBW7_2	0.1389
p.E640G	SIDM00332	Breast Carcinoma	GDSC	VETPLEE	DEG_SCF_FBW7_2	0.0556
p.E640G	ACH-001819	Breast Cancer	CCLE	VETPLEE	DEG_SCF_FBW7_2	0.0556
p.E640G	MFM-223	breast	COSMIC	VETPLEE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXJ9	N-alpha-acetyltransferase 15, NatA auxiliary subunit	DEG_SCF_FBW7_2	650:656	VETPLEE	FBXW7	0.7414	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons