DegronMD

Uniprot ID: P49792

Source protein: E3 SUMO-protein ligase RanBP2

Source gene: RANBP2

Class: DEG_SCF_FBW7_2

Location: 1141:1148

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 78.6875

COIL: 0.8193

CONS_SCORE: 0.3589

DSS_SCORE: 0.6294

HELIX: 0.0553

FCONS_SCORE: 0.9366

RIG_SCORE: 0.6868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1137S	TCGA-14-1795	GBM	TCGA	VFGTPTLE	DEG_SCF_FBW7_2	0.2222
p.P1137S	TCGA-OR-A5K9	ACC	TCGA	VFGTPTLE	DEG_SCF_FBW7_2	0.2222
p.P1137S	DO13114	GBM	ICGC	VFGTPTLE	DEG_SCF_FBW7_2	0.2222
p.K1152N	TCGA-B5-A1MR	UCEC	TCGA	VFGTPTLE	DEG_SCF_FBW7_2	0.3333
p.K1152N	DO41758	UCEC	ICGC	VFGTPTLE	DEG_SCF_FBW7_2	0.3333
p.N1151S	TCGA-BC-A10Q	LIHC	TCGA	VFGTPTLE	DEG_SCF_FBW7_2	0.25
p.N1151S	DO22887	LIHC	ICGC	VFGTPTLE	DEG_SCF_FBW7_2	0.25
p.F1134L	TCGA-DX-AB2Q	SARC	TCGA	VFGTPTLE	DEG_SCF_FBW7_2	0.1389
p.F1134L	DO220087	SARC	ICGC	VFGTPTLE	DEG_SCF_FBW7_2	0.1389
p.G1136D	TCGA-IB-7651	PAAD	TCGA	VFGTPTLE	DEG_SCF_FBW7_2	0.1944
p.G1136D	DO46657	PAAD	ICGC	VFGTPTLE	DEG_SCF_FBW7_2	0.1944
p.V1141L	DO229019	LICA	ICGC	VFGTPTLE	DEG_SCF_FBW7_2	0.5654
p.G1138W	DO229036	LICA	ICGC	VFGTPTLE	DEG_SCF_FBW7_2	0.25
p.F1142C	DO44668	LICA	ICGC	VFGTPTLE	DEG_SCF_FBW7_2	0.5996
p.H1154L	SIDM01117	Small Cell Lung Carcinoma	GDSC	VFGTPTLE	DEG_SCF_FBW7_2	0.1667
p.S1140L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	VFGTPTLE	DEG_SCF_FBW7_2	0.75
p.S1140L	ACH-000583	Lymphoma	CCLE	VFGTPTLE	DEG_SCF_FBW7_2	0.75
p.S1140L	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	VFGTPTLE	DEG_SCF_FBW7_2	0.75
p.V1141A	SIDM00522	Small Cell Lung Carcinoma	GDSC	VFGTPTLE	DEG_SCF_FBW7_2	0.6936
p.V1141A	ACH-000749	Lung Cancer	CCLE	VFGTPTLE	DEG_SCF_FBW7_2	0.6936
p.V1141A	DMS-273	lung	COSMIC	VFGTPTLE	DEG_SCF_FBW7_2	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SCF_FBW7_2	1141:1148	VFGTPTLE	FBXW7	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons