DegronMD

Uniprot ID: P55259

Source protein: Pancreatic secretory granule membrane major glycoprotein GP2

Source gene: GP2

Class: LIG_APCC_ABBA_1

Location: 457:462

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5724

ASA_SCORE: 24.9167

COIL: 0.022

CONS_SCORE: 0.7716

DSS_SCORE: 0.0122

HELIX: 0.0017

FCONS_SCORE: 1.3753

RIG_SCORE: 0.931

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L469I	TCGA-05-4396	LUAD	TCGA	VFLHCE	LIG_APCC_ABBA_1	0.1389
p.M447V	TCGA-43-6143	LUSC	TCGA	VFLHCE	LIG_APCC_ABBA_1	0.0556
p.H453Q	TCGA-A5-A2K5	UCEC	TCGA	VFLHCE	LIG_APCC_ABBA_1	0.2222
p.S468Y	TCGA-BS-A0UF	UCEC	TCGA	VFLHCE	LIG_APCC_ABBA_1	0.1667
p.E462K	TCGA-IN-A6RP	STAD	TCGA	VFLHCE	LIG_APCC_ABBA_1	0.7022
p.L459R	TCGA-YG-AA3O	SKCM	TCGA	VFLHCE	LIG_APCC_ABBA_1	0.8428
p.L466I	DO23838	LUAD	ICGC	VFLHCE	LIG_APCC_ABBA_1	0.2222
p.F458L	SIDM01206	Neuroblastoma	GDSC	VFLHCE	LIG_APCC_ABBA_1	0.587
p.F458L	ACH-000310	Neuroblastoma	CCLE	VFLHCE	LIG_APCC_ABBA_1	0.587
p.F458L	ACH-002248	Neuroblastoma	CCLE	VFLHCE	LIG_APCC_ABBA_1	0.587
p.F458L	IMR-5	autonomic_ganglia	COSMIC	VFLHCE	LIG_APCC_ABBA_1	0.587
p.F455L	IMR-5	autonomic_ganglia	COSMIC	VFLHCE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55259	Pancreatic secretory granule membrane major glycoprotein GP2	LIG_APCC_ABBA_1	457:462	VFLHCE	APC,CDC20,FZR1	0.5724	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons