DegronMD

Uniprot ID: P49792

Source protein: E3 SUMO-protein ligase RanBP2

Source gene: RANBP2

Class: DEG_SCF_FBW7_1

Location: 1394:1400

E3 ligase: FBXW7

DEGRON score: 0.5963

ASA_SCORE: 74.6

COIL: 0.859

CONS_SCORE: 0.2645

DSS_SCORE: 0.4842

HELIX: 0.0153

FCONS_SCORE: 0.949

RIG_SCORE: 0.739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1404F	TCGA-49-4487	LUAD	TCGA	VFTPKTS	DEG_SCF_FBW7_1	0.2222
p.V1404F	DO24780	LUAD	ICGC	VFTPKTS	DEG_SCF_FBW7_1	0.2222
p.T1396I	TCGA-98-8021	LUSC	TCGA	VFTPKTS	DEG_SCF_FBW7_1	0.8189
p.T1396I	DO27468	LUSC	ICGC	VFTPKTS	DEG_SCF_FBW7_1	0.8189
p.R1407Q	TCGA-AP-A056	UCEC	TCGA	VFTPKTS	DEG_SCF_FBW7_1	0.1389
p.R1407Q	DO43971	UCEC	ICGC	VFTPKTS	DEG_SCF_FBW7_1	0.1389
p.A1409T	TCGA-EY-A215	UCEC	TCGA	VFTPKTS	DEG_SCF_FBW7_1	0.0833
p.A1409T	DO42665	UCEC	ICGC	VFTPKTS	DEG_SCF_FBW7_1	0.0833
p.P1389L	TCGA-LN-A49P	ESCA	TCGA	VFTPKTS	DEG_SCF_FBW7_1	0.1944
p.V1386F	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	VFTPKTS	DEG_SCF_FBW7_1	0.1111
p.V1386F	ACH-000021	Lung Cancer	CCLE	VFTPKTS	DEG_SCF_FBW7_1	0.1111
p.V1386F	ACH-000033	Lung Cancer	CCLE	VFTPKTS	DEG_SCF_FBW7_1	0.1111
p.V1386F	NCI-H1693	lung	COSMIC	VFTPKTS	DEG_SCF_FBW7_1	0.1111
p.V1404I	SIDM00156	Neuroblastoma	GDSC	VFTPKTS	DEG_SCF_FBW7_1	0.2222
p.V1404I	NB7	autonomic_ganglia	COSMIC	VFTPKTS	DEG_SCF_FBW7_1	0.2222
p.S1400N	SIDM00516	Melanoma	GDSC	VFTPKTS	DEG_SCF_FBW7_1	0.818
p.S1400N	ACH-002166	Skin Cancer	CCLE	VFTPKTS	DEG_SCF_FBW7_1	0.818
p.S1400N	MZ7-mel	skin	COSMIC	VFTPKTS	DEG_SCF_FBW7_1	0.818
p.S1400R	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	VFTPKTS	DEG_SCF_FBW7_1	0.8538
p.S1400R	ACH-000628	Lung Cancer	CCLE	VFTPKTS	DEG_SCF_FBW7_1	0.8538
p.S1400R	NCI-H596	lung	COSMIC	VFTPKTS	DEG_SCF_FBW7_1	0.8538

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SCF_FBW7_1	1394:1400	VFTPKTS	FBXW7	0.5963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons