DegronMD

Uniprot ID: Q99460

Source protein: 26S proteasome non-ATPase regulatory subunit 1

Source gene: PSMD1

Class: DEG_SCF_FBW7_1

Location: 308:315

E3 ligase: FBXW7

DEGRON score: 0.8948

ASA_SCORE: 73.325

COIL: 0.8528

CONS_SCORE: 0.239

DSS_SCORE: 0.7043

HELIX: 0.0969

FCONS_SCORE: 0.9158

RIG_SCORE: 0.6334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E300Q	TCGA-E2-A10C	BRCA	TCGA	VGKTPEAS	DEG_SCF_FBW7_1	0.1111
p.E300Q	DO1334	BRCA	ICGC	VGKTPEAS	DEG_SCF_FBW7_1	0.1111
p.F307L	TCGA-VQ-A8P3	STAD	TCGA	VGKTPEAS	DEG_SCF_FBW7_1	0.3056
p.F307L	DO51762	STAD	ICGC	VGKTPEAS	DEG_SCF_FBW7_1	0.3056
p.S305I	DO229028	LICA	ICGC	VGKTPEAS	DEG_SCF_FBW7_1	0.6944
p.G309V	DO229035	LICA	ICGC	VGKTPEAS	DEG_SCF_FBW7_1	0.6421
p.E313Q	SIDM00963	Breast Carcinoma	GDSC	VGKTPEAS	DEG_SCF_FBW7_1	0.5633
p.E313Q	ACH-000927	Breast Cancer	CCLE	VGKTPEAS	DEG_SCF_FBW7_1	0.5633
p.E313Q	BT-474	breast	COSMIC	VGKTPEAS	DEG_SCF_FBW7_1	0.5633
p.E313K	ACH-000489	Colon/Colorectal Cancer	CCLE	VGKTPEAS	DEG_SCF_FBW7_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99460	26S proteasome non-ATPase regulatory subunit 1	DEG_SCF_FBW7_1	308:315	VGKTPEAS	FBXW7	0.8948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons