DegronMD - Q99460(PSMD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A276S	TCGA-CC-5259	LIHC	TCGA	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation altering degron motif	0.6477
p.A276S	DO44886	LIHC	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation altering degron motif	0.6477
p.I275V	TCGA-DX-A7ES	SARC	TCGA	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation altering degron motif	0.5965
p.I275V	DO220036	SARC	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation altering degron motif	0.5965
p.E300Q	TCGA-E2-A10C	BRCA	TCGA	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation rewiring degron network	0.1111
p.E300Q	DO1334	BRCA	ICGC	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation rewiring degron network	0.1111
p.F307L	TCGA-VQ-A8P3	STAD	TCGA	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation rewiring degron network	0.3056
p.F307L	DO51762	STAD	ICGC	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation rewiring degron network	0.3056
p.I265F	DO229323	BTCA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.1667
p.L261F	DO229029	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.0556
p.S305I	DO229028	LICA	ICGC	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation blocking phosphorylation signal	0.6944
p.V264L	DO229027	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.1389
p.G272V	DO229026	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation altering degron motif	0.6421
p.V271F	DO229031	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation altering degron motif	0.7068
p.G309V	DO229035	LICA	ICGC	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation altering degron motif	0.6421
p.T284M	DO229053	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation blocking phosphorylation signal	0.5833
p.N267S	DO231043	LUSC	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.2222
p.G272S	DO228238	MALY	ICGC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation altering degron motif	0.5882
p.R269Q	SIDM00186	Kidney Carcinoma	GDSC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.2778
p.R269Q	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.2778
p.R269Q	SIDM01651	Non-Cancerous	GDSC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.2778
p.R269Q	SIDM00920	Breast Carcinoma	GDSC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.2778
p.R269Q	SIDM00673	Breast Carcinoma	GDSC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.2778
p.E313Q	SIDM00963	Breast Carcinoma	GDSC	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation altering degron motif	0.5633
p.E313Q	ACH-000927	Breast Cancer	CCLE	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation altering degron motif	0.5633
p.E313Q	BT-474	breast	COSMIC	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation altering degron motif	0.5633
p.T286A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.0833
p.T286A	ACH-000937	Leukemia	CCLE	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.0833
p.T286A	PF-382	haematopoietic and lymphoid tissue	COSMIC	VGTPIAS	DEG_SCF_FBW7_1	271:277	Mutation rewiring degron network	0.0833
p.E313K	ACH-000489	Colon/Colorectal Cancer	CCLE	VGKTPEAS	DEG_SCF_FBW7_1	308:315	Mutation altering degron motif	0.591

Kaplan plot for PSMD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSMD1

UniProt ID: Q99460

Entrez ID: 5707

Protein name: 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSMD1 in