DegronMD

Uniprot ID: Q99460

Source protein: 26S proteasome non-ATPase regulatory subunit 1

Source gene: PSMD1

Class: DEG_SCF_FBW7_1

Location: 271:277

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 67.3286

COIL: 0.9034

CONS_SCORE: 0.2633

DSS_SCORE: 0.4107

HELIX: 0.036

FCONS_SCORE: 0.8114

RIG_SCORE: 0.7248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A276S	TCGA-CC-5259	LIHC	TCGA	VGTPIAS	DEG_SCF_FBW7_1	0.6477
p.A276S	DO44886	LIHC	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.6477
p.I275V	TCGA-DX-A7ES	SARC	TCGA	VGTPIAS	DEG_SCF_FBW7_1	0.5965
p.I275V	DO220036	SARC	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.5965
p.I265F	DO229323	BTCA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.1667
p.L261F	DO229029	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.0556
p.V264L	DO229027	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.1389
p.G272V	DO229026	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.6421
p.V271F	DO229031	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.7068
p.T284M	DO229053	LICA	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.5833
p.N267S	DO231043	LUSC	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.2222
p.G272S	DO228238	MALY	ICGC	VGTPIAS	DEG_SCF_FBW7_1	0.5882
p.R269Q	SIDM00186	Kidney Carcinoma	GDSC	VGTPIAS	DEG_SCF_FBW7_1	0.2778
p.R269Q	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	VGTPIAS	DEG_SCF_FBW7_1	0.2778
p.R269Q	SIDM01651	Non-Cancerous	GDSC	VGTPIAS	DEG_SCF_FBW7_1	0.2778
p.R269Q	SIDM00920	Breast Carcinoma	GDSC	VGTPIAS	DEG_SCF_FBW7_1	0.2778
p.R269Q	SIDM00673	Breast Carcinoma	GDSC	VGTPIAS	DEG_SCF_FBW7_1	0.2778
p.T286A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VGTPIAS	DEG_SCF_FBW7_1	0.0833
p.T286A	ACH-000937	Leukemia	CCLE	VGTPIAS	DEG_SCF_FBW7_1	0.0833
p.T286A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VGTPIAS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99460	26S proteasome non-ATPase regulatory subunit 1	DEG_SCF_FBW7_1	271:277	VGTPIAS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons